85108-59-4Relevant academic research and scientific papers
Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis
Santiva?ez-Veliz, Mery,Pérez-Silanes, Silvia,Torres, Enrique,Moreno-Viguri, Elsa
, p. 2188 - 2193 (2016)
Twenty-four quinoxaline derivatives were evaluated for their antimycobacterial activity using BacTiter-Glo microbial cell viability assay. Five compounds showed MIC values 50 values 1.5 μM in primary screening and therefore, they
Preparation method of antibacterial veterinary medicine quinocetone
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Paragraph 0015; 0016; 0017; 0018; 0019, (2017/08/29)
The invention provides a preparation method of quinocetone which is a national first class new veterinary medicine initiated internationally and has antibacterial, diarrhea-stopping and growth-promoting effects. The preparation method comprises the following steps: adding alkaline ionic liquid into a reactor, adding benzofurazan and benzylidene acetylacetone, stirring, conducting reaction at room temperature, and performing aftertreatment on the reaction liquid after the reaction to obtain the quinocetone. The method is short in process step, mild in reaction condition, short in reaction time, high in efficiency, high in product yield and high in product purity; meanwhile, the alkaline ionic liquid provided by the invention is in a liquid state at room temperature, has high dissolubility on the raw materials and can serve as a catalyst and a reaction solvent of a reaction system, so that environmental pollution caused by an organic solvent is avoided and large-scale production is facilitated.
2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: A novel cluster of tumor-specific cytotoxins which reverse multidrug resistance
Das, Umashankar,Pati, Hari N.,Panda, Atulya K.,Clercq, Erik De,Balzarini, Jan,Molnar, Joseph,Barath, Zoltan,Ocsovszki, Imre,Kawase, Masami,Zhou, Li,Sakagami, Hiroshi,Dimmock, Jonathan R.
experimental part, p. 3909 - 3915 (2009/10/02)
A series of 2-(3-aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides 3a-l were prepared by condensation of various aryl aldehydes with 2-acetyl-3-methylquinoxaline-1,4-dioxide 2. These compounds inhibit the growth of human Molt 4/C8 and CEM T-lymphocytes a
2-(3-Arylacryloyl)-3-methylquinoxaline 1,4-dioxides as potential hypoxic selective cytotoxins
Dittenhafer, Kristin,Das, Umashankar,Younglove, Brent L.,Mackay, Hilary,Brown, Toni,Dimmock, Jonathan R.,Lee, Moses,Pati, Hari
body text, p. 385 - 388 (2009/05/31)
The synthesis of a series of 2-(3-arylacryloyl)-3-methylquinoxaline 1,4-dioxides is reported. In-vitro cytotoxic activity of these compounds was evaluated via the MTT assay in B16 murine melanoma and L1210 murine leukemia cell lines. A dichloro analogue w
A new Route for the Synthesis of Phenazine Di-N-Oxides
El-Halim, M. S. Abd,El-Ahl, A. S.,Etman, H. A.,Ali, M. M.,Fouda, A.,Fadda, A. A.
, p. 1217 - 1224 (2007/10/03)
Several phenazine 5,10-dioxides (7a-d) were prepared by the reaction of 2-methyl-3-acetylquinoxaline 1,4-dioxide (2) with different aromatic aldehydes or by direct cyclization of the quinoxaline cinnamoyl derivatives 3 in basic medium.In addition, the phe
