851096-54-3Relevant academic research and scientific papers
Total synthesis of (-)-heliespirone a and (+)-heliespirone C
Norcott, Philip,McErlean, Christopher S. P.
, p. 5056 - 5062 (2014/08/18)
Total syntheses of the spiro-epimeric natural products (-)-heliespirone A and (+)-heliespirone C are described. The successful strategy involved an aromatic Claisen rearrangement, a diastereoselective Sharpless asymmetric dihydroxylation (AD) reaction, and an intramolecular oxa-Michael addition.
Total synthesis of (±)-heliannuol C and E via aromatic Claisen rearrangement
Vyvyan, James R.,Oaksmith, Jennifer M.,Parks, Bevin W.,Peterson, Elaine M.
, p. 2457 - 2460 (2007/10/03)
The total synthesis of heliannuol C and E from a common intermediate are described. Key steps in the synthesis include a regioselective aromatic Claisen rearrangement to install the (1-vinyl)-4-methyl-3-pentenyl substituent and regioselective biomimetic 7
