85112-64-7

Upstream product

• 100-60-7 N-methylcyclohexylamine 
• 67193-97-9 7-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 105763-60-8 4-(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yloxy)-butyric acid ethyl ester 
• 85112-77-2 4-(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yloxy)-butyric acid 

Relevant academic research and scientific papers

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide

Evaluation of a series of lactam heterocyclic analogues of cilostamide as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding methoxy-substituted heterocycles has revealed that the N-cyclohexyl-N-methyl-4-oxybutyramide side chain of 2 is an important lipophilic and/or steric pharmacophore. Attachment of this side chain to the parent heterocycle of the potent cyclic AMP phosphodiesterase inhibitor anagrelide afforded the hybrid structure RS-82856, shown to be more potent than either of its progenitors as an inhibitor of cyclic AMP phosphodiesterase or of ADP-induced platelet aggregation. The available in vitro data suggest that 1 possesses potentially useful antithrombotic and cardiotonic properties.