851175-95-6 Usage
Chemical Class
Pyrazolopyridine carboxylic acids
Explanation
1-ISOPROPYL-6-PHENYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID belongs to the class of pyrazolopyridine carboxylic acids, which are heterocyclic compounds with potential biological activities.
Explanation
The compound features a heterocyclic structure consisting of a pyrazole and a pyridine ring system, which contributes to its potential biological activities and applications in medicinal chemistry.
Explanation
The presence of an isopropyl group at position 1 and a phenyl group at position 6 on the pyrazolopyridine ring provides unique structural features and functional groups that may influence its properties and potential applications.
Explanation
1-ISOPROPYL-6-PHENYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID is often used as a building block in the synthesis of pharmaceutical compounds, which may lead to the development of new drugs and therapies.
Explanation
Due to its structural features and functional groups, the compound may have applications in medicinal chemistry and drug discovery, although further research is needed to fully understand its properties and potential uses in various fields.
Structure
Pyrazole and pyridine ring system
Substituents
Isopropyl and phenyl groups
Synthesis building block
Pharmaceutical compounds
Potential applications
Medicinal chemistry and drug discovery
Check Digit Verification of cas no
The CAS Registry Mumber 851175-95-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,7 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 851175-95:
(8*8)+(7*5)+(6*1)+(5*1)+(4*7)+(3*5)+(2*9)+(1*5)=176
176 % 10 = 6
So 851175-95-6 is a valid CAS Registry Number.
851175-95-6Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication
Xing, Yanpeng,Zuo, Jun,Krogstad, Paul,Jung, Michael E.
, p. 1688 - 1703 (2018/03/06)
A series of novel pyrazolopyridine compounds have been designed and prepared by a general synthetic route. Their activities against the replication of poliovirus-1, EV-A71, and CV-B3 enteroviruses were evaluated. The comprehensive understanding of the structure-activity relationship was obtained by utilizing the variation of four positions, namely, N1, C6, C4, and linker unit. From the screened analogues, the inhibitors with the highest selectivity indices at 50% inhibition of viral replication (SI50) were those with isopropyl at the N1 position and thiophenyl-2-yl unit at C6 position. Furthermore, the C4 position offered the greatest potential for improvement because many different N-aryl groups had better antiviral activities and compatibilities than the lead compound JX001. For example, JX040 with a 2-pyridyl group was the analogue with the most potent activity against non-polio enteroviruses, and JX025, possessing a 3-sulfamoylphenyl moiety, had the best activity against polioviruses. In addition, analogue JX037, possessing a novel pyrazolopyridine heterocycle, was also shown to have good antienteroviral activity, which further enlarges the compound space for antienteroviral drug design.
