851178-99-9

Basic information

• Product Name: 4-Chloro-2,3-difluoropyridine
• Synonyms: Pyridine,4-chloro-2,3-difluoro-;2,3-dichloro-4-fluoropyridine
• CAS NO: 851178-99-9
• Molecular Formula: C5H2ClF2N
• Molecular Weight: 149.53
• EINECS: 200-158-5
• Product Categories: API intermediates
• Mol File: 851178-99-9.mol

Chemical Properties

• Melting Point: -25--23℃
• Boiling Point: 141-142℃
• Flash Point: 44.497 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 5.001mmHg at 25°C
• Refractive Index: 1.4726 (589.3 nm 20℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.47±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-2,3-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2,3-difluoropyridine(851178-99-9)
• EPA Substance Registry System: 4-Chloro-2,3-difluoropyridine(851178-99-9)

Safety Data

• Hazardous Substances Data: 851178-99-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2,3-difluoropyridine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs due to its unique reactivity and structural properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-2,3-difluoropyridine is utilized as a precursor in the production of insecticides and herbicides, enhancing the effectiveness of these products in pest and weed control.
Used in Organic Synthesis:
As a reagent in organic chemistry, 4-Chloro-2,3-difluoropyridine is employed in a variety of reactions, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical research.
Used in Research and Development:
4-Chloro-2,3-difluoropyridine is also used as a research chemical, aiding in the exploration and development of novel pharmaceuticals and agrochemicals, thanks to its distinctive properties and high reactivity.
It is crucial to handle 4-Chloro-2,3-difluoropyridine with care due to its potential hazards if not properly managed.

InChI:InChI=1/C5H2ClF2N/c6-3-1-2-9-5(8)4(3)7/h1-2H

Upstream product

• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 1513-66-2 2,3-difluoropyridine 

Downstream Products

• 82878-63-5 3,4-difluoropyridine 

Relevant articles and documents

N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65

One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5 or 6 membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11',OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11' OH, alkyl, haloalkyl, and aralkyl; Y is selected from C=N-OH and CR10R10' wherein R10 and R10' are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R11 and R11' are each independently selected from H, alkyl, haloalkyl, COR12, and SO2R13, wherein R12 and R13 are both alkyl; for use as a medicament. Further aspects of the invention relate to compounds of formula (I) for use in the field of immuno-oncology, immunology, and related applications, and compounds of formula (I) per se.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.