851178-99-9

Basic information

• Product Name: 4-Chloro-2,3-difluoropyridine
• Synonyms: Pyridine,4-chloro-2,3-difluoro-;2,3-dichloro-4-fluoropyridine
• CAS NO: 851178-99-9
• Molecular Formula: C5H2ClF2N
• Molecular Weight: 149.53
• EINECS: 200-158-5
• Product Categories: API intermediates
• Mol File: 851178-99-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: -25--23℃
• Boiling Point: 141-142℃
• Flash Point: 44.497 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 5.001mmHg at 25°C
• Refractive Index: 1.4726 (589.3 nm 20℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.47±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-2,3-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2,3-difluoropyridine(851178-99-9)
• EPA Substance Registry System: 4-Chloro-2,3-difluoropyridine(851178-99-9)

Safety Data

• Hazardous Substances Data: 851178-99-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-2,3-difluoropyridine is a chemical compound with the molecular formula C5H2ClF2N. It is a colorless to light yellow liquid that is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. 4-Chloro-2,3-difluoropyridine is known for its high reactivity due to the presence of the chlorine and fluorine atoms, making it a versatile building block in organic synthesis. It is commonly used as a reagent in organic chemistry reactions, as well as in the production of insecticides and herbicides. Additionally, 4-Chloro-2,3-difluoropyridine is also used as a research chemical in the development of new pharmaceuticals and agrochemicals due to its unique properties. However, it is important to handle this compound with caution, as it can be hazardous if not properly managed.

InChI:InChI=1/C5H2ClF2N/c6-3-1-2-9-5(8)4(3)7/h1-2H

Upstream product

• 1513-66-2 2,3-difluoropyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 82878-63-5 3,4-difluoropyridine 

Relevant articles and documents

N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65

One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5 or 6 membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11',OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11' OH, alkyl, haloalkyl, and aralkyl; Y is selected from C=N-OH and CR10R10' wherein R10 and R10' are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R11 and R11' are each independently selected from H, alkyl, haloalkyl, COR12, and SO2R13, wherein R12 and R13 are both alkyl; for use as a medicament. Further aspects of the invention relate to compounds of formula (I) for use in the field of immuno-oncology, immunology, and related applications, and compounds of formula (I) per se.