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4-Chloro-2,3-difluoropyridine, with the molecular formula C5H2ClF2N, is a colorless to light yellow liquid chemical compound. It is recognized for its high reactivity due to the chlorine and fluorine atoms, which make it a versatile building block in organic synthesis. 4-Chloro-2,3-difluoropyridine is primarily utilized as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals, and also serves as a reagent in organic chemistry reactions.

851178-99-9

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851178-99-9 Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2,3-difluoropyridine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs due to its unique reactivity and structural properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-2,3-difluoropyridine is utilized as a precursor in the production of insecticides and herbicides, enhancing the effectiveness of these products in pest and weed control.
Used in Organic Synthesis:
As a reagent in organic chemistry, 4-Chloro-2,3-difluoropyridine is employed in a variety of reactions, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical research.
Used in Research and Development:
4-Chloro-2,3-difluoropyridine is also used as a research chemical, aiding in the exploration and development of novel pharmaceuticals and agrochemicals, thanks to its distinctive properties and high reactivity.
It is crucial to handle 4-Chloro-2,3-difluoropyridine with care due to its potential hazards if not properly managed.

Check Digit Verification of cas no

The CAS Registry Mumber 851178-99-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,1,7 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 851178-99:
(8*8)+(7*5)+(6*1)+(5*1)+(4*7)+(3*8)+(2*9)+(1*9)=189
189 % 10 = 9
So 851178-99-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H2ClF2N/c6-3-1-2-9-5(8)4(3)7/h1-2H

851178-99-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-2,3-difluoropyridine

1.2 Other means of identification

Product number -
Other names 4-chloro-2,3-difluoro-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:851178-99-9 SDS

851178-99-9Downstream Products

851178-99-9Relevant articles and documents

N-PHENYLAMINOCARBONYL PYRIDINO-, PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65

-

Page/Page column 228; 229, (2021/12/12)

One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein: ring A is a 5 or 6 membered aromatic or heteroaromatic ring, wherein said aromatic or heteroaromatic ring is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11',OH, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11' OH, alkyl, haloalkyl, and aralkyl; Y is selected from C=N-OH and CR10R10' wherein R10 and R10' are each independently selected from H, F, alkyl, and haloalkyl; R1, R4, and R5 are each independently selected from H, F, Cl, Br, and I; R2 and R3 are each independently selected from H, F, Cl, Br, I, CN, methoxy, and haloalkyl; and R11 and R11' are each independently selected from H, alkyl, haloalkyl, COR12, and SO2R13, wherein R12 and R13 are both alkyl; for use as a medicament. Further aspects of the invention relate to compounds of formula (I) for use in the field of immuno-oncology, immunology, and related applications, and compounds of formula (I) per se.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Bobbio, Carla,Rausis, Thierry,Schlosser, Manfred

, p. 1903 - 1910 (2007/10/03)

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.

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