85118-28-1

Basic information

• Product Name: ethyl 3-(dimethylamino)butyrate
• Synonyms: ethyl 3-(dimethylamino)butyrate;3-(Dimethylamino)butanoic acid ethyl ester;Einecs 285-681-4
• CAS NO: 85118-28-1
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.22608
• EINECS: 285-681-4
• Mol File: 85118-28-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 188.6°Cat760mmHg
• Flash Point: 62.2°C
• Appearance: /
• Density: 0.927g/cm³
• Vapor Pressure: 0.593mmHg at 25°C
• Refractive Index: 1.432
• CAS DataBase Reference: ethyl 3-(dimethylamino)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(dimethylamino)butyrate(85118-28-1)
• EPA Substance Registry System: ethyl 3-(dimethylamino)butyrate(85118-28-1)

Safety Data

• Hazardous Substances Data: 85118-28-1(Hazardous Substances Data)

Usage

Uses

Ethyl 3-(Dimethylamino)butanoate is an intermediate in the synthesis of Dimethylthiambutene Hydrochloride (D479490), which is an opioid analgesic drug used in veterinary medicine.

InChI:InChI=1/C8H17NO2/c1-5-11-8(10)6-7(2)9(3)4/h7H,5-6H2,1-4H3

Upstream product

• 2835-82-7 3-aminobutyric acid 
• 14205-42-6 3-dimethylamino-crotonic acid ethyl ester 
• 64-17-5 ethanol 
• 5303-65-1 3-aminobutanoic acid ethyl ester 
• 74-88-4 methyl iodide 
• 557087-01-1 2-dimethylamino-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 10544-63-5 ethyl crotonate 
• 141-97-9 ethyl acetoacetate 
• 1117-37-9 ethyl (E)-3-(dimethylamino)acrylate 
• 917-54-4 methyllithium 
• 124-40-3 dimethyl amine 
• 623-70-1 ethyl (E)-crotonate 

Downstream Products

• 2893-65-4 γ-dimethylamino-butyl alcohol 

Relevant articles and documents

Alkoxide activation of aminoboranes towards selective amination

Piece of the (inter)action: The interaction of alkoxides with the sp 2 Bpin (pin=pinacol) moiety in aminoboranes forms the in situ Lewis acid-base adduct [RO-→B(OR)2-N(R′)2] which enables the amino moiety to react as a strong nucleophile with several electrophiles, thus providing amino alcohols, β-enamino esters, and β-hydroxy amides in a direct and remarkably selective way (see scheme). Copyright

New synthesis of β-aminoacid derivatives via hydroamination in Dimcarb

A new selective hydro-dimethylamination method for unsaturated carboxylic acid derivatives with the pronucleophilic dimethylamine-precursor Dimcarb is described, which allows effective synthesis of hydro-β-dimethylamino-acid derivatives and unsaturated amides. Simple HMO quantum chemical calculation together with 1H NMR examination permits the prediction of suitable substrates, coupling position for dimethylamine as well as for mechanistical insights and optimal reaction course.