85120-52-1Relevant academic research and scientific papers
Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network
Faller, Bernard,Spanka, Carsten,Sergejew, Thomas,Tschinke, Vincenzo
, p. 1467 - 1475 (2007/10/03)
Physicochemical analysis and Monte Carlo simulations were used to identify structural features which prevent oral absorption of HBED, a potent iron chelator. In water the dominant conformations of HBED involve the hydrophobic collapse of the two aromatic
Esters and Lactones of Phenolic Amino Carboxylic Acids: Prodrugs for Iron Chelation
Pitt, C. G.,Bao, Y.,Thompson, J.,Wani, M. C.,Rosenkrantz, H.,Metterville, J.
, p. 1231 - 1237 (2007/10/02)
The new iron chelator N,N'-bis(2-hydroxyphenyl)ethylenediamine-N,N'-diacetic acid (1), its dilactone 2, N,N'-bis(2-hydroxybenzyl)-2-hydroxypropylene-1,3-diamine-N,N'-diacetic acid (3), and its methyl ester lactone 4 and a series of esters of N,N'-bis(2-hy
