851224-64-1

Basic information

• Product Name: 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester
• Synonyms: 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester
• CAS NO: 851224-64-1
• Molecular Weight: 480.508
• Mol File: 851224-64-1.mol

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester(851224-64-1)
• EPA Substance Registry System: 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester(851224-64-1)

Safety Data

• Hazardous Substances Data: 851224-64-1(Hazardous Substances Data)

Upstream product

• 851224-81-2 [3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-yl]methanol 
• 851224-79-8 5-(4-trifluoromethylphenyl)[1,3,4]oxathiazol-2-one 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 1891-90-3 p-trifluoromethylbenzamide 
• 95-71-6 2-methylbenzene-1,4-diol 
• 851224-83-4 mesylate 
• 328919-32-0 2-(4-Hydroxy-2-methyl-phenoxy)-2-methyl-propionic Acid Ethyl Ester 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 435303-23-4 2-(4-acetyl-2-methylphenoxy)-2-methylpropionic acid ethyl ester 
• 600-00-0 ethyl 2-bromoisobutyrate 
• 947599-52-2 5-bromomethyl-3-(4-trifluoromethylphenyl)[1,2,4]thiadiazole 

Relevant articles and documents

Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4] thiadiazole derivative: A promising PPARα,δ agonist

The preparation of the PPARα,δ agonist 2-methyl-2-(2-methyl-4- (3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazol-5-ylmethoxy)phenoxy)propionic acid sodium salt (17) is described and compared with earlier in-house preparations of this important target compound. Key concerns around a large-scale synthesis of this thiadiazole derivative were a large number of purification steps, the use of dichlorobenzene as a solvent, and a possible large-scale Baeyer-Villiger oxidation. This paper describes a straightforward preparation of the target agonist using methylhydroquinone (MHQ) as an inexpensive precursor that eliminates the need of an oxidation step.

Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors α and δ

Cardiovascular disease is the most common cause of morbidity and mortality in developed nations. To effectively target dyslipidemia to reduce the risk of cardiovascular disease, it may be beneficial to activate the peroxisome proliferator-activated recept

4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.