851224-81-2

Basic information

• Product Name: (3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL
• Synonyms: (3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL
• CAS NO: 851224-81-2
• Molecular Formula: C₁₀H₇F₃N₂OS
• Molecular Weight: 0
• Mol File: 851224-81-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL(851224-81-2)
• EPA Substance Registry System: (3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL(851224-81-2)

Safety Data

• Hazardous Substances Data: 851224-81-2(Hazardous Substances Data)

Upstream product

• 851224-80-1 3-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-5-carboxylic acid ethyl ester 
• 851224-79-8 5-(4-trifluoromethylphenyl)[1,3,4]oxathiazol-2-one 
• 1891-90-3 p-trifluoromethylbenzamide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 851224-83-4 mesylate 
• 851224-87-8 2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethylsulfanyl]phenol 
• 851224-64-1 2-methyl-2-{2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethoxy]phenoxy}propionic acid ethyl ester 
• 851224-82-3 {2-methyl-4-[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-ylmethylsulfanyl]phenoxy}acetic acid ethyl ester 

Relevant articles and documents

Synthesis and identification of [1,2,4]thiadiazole derivatives as a new series of potent and orally active dual agonists of peroxisome proliferator-activated receptors α and δ

Cardiovascular disease is the most common cause of morbidity and mortality in developed nations. To effectively target dyslipidemia to reduce the risk of cardiovascular disease, it may be beneficial to activate the peroxisome proliferator-activated recept

Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4] thiadiazole derivative: A promising PPARα,δ agonist

The preparation of the PPARα,δ agonist 2-methyl-2-(2-methyl-4- (3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazol-5-ylmethoxy)phenoxy)propionic acid sodium salt (17) is described and compared with earlier in-house preparations of this important target compound. Key concerns around a large-scale synthesis of this thiadiazole derivative were a large number of purification steps, the use of dichlorobenzene as a solvent, and a possible large-scale Baeyer-Villiger oxidation. This paper describes a straightforward preparation of the target agonist using methylhydroquinone (MHQ) as an inexpensive precursor that eliminates the need of an oxidation step.

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndr

4-((Phenoxyalkyl)thio)-phenoxyacetic acids and analogs

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.