851279-17-9

Upstream product

• 86546-84-1 (5S,8R,10S)-drim-9⁽¹¹⁾-en-8-ol 
• 316803-64-2 Acetic acid (1R,2R,4aS,8aS)-1-iodomethyl-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-yl ester 
• 851279-15-7 3,4-di-benzyloxy-6-(7'-drimen-11'-ylidene)-2,4-cyclohexadienone 
• 105426-71-9 (1S,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-2,5,58a-tetramethylnaphtahelene-1-carboxaldehyde 
• 468-68-8 (-)-drimenol 
• 52617-99-9 (+)-drimane-8,11-diol 
• 27688-86-4 3,4-dibenzyloxyphenol 
• 851279-14-6 4,5-di-O-benzyl-2-bromo-1O-diethylcarbamoylbenzenetriol 
• 851279-13-5 1,2-di-O-benzyl-4-O-diethylcarbamoylbenzenetriol 

Relevant academic research and scientific papers

First enantiospecific synthesis of the antitumor marine sponge metabolite (-)-15-oxopuupehenol from (-)-sclareol

(Chemical Equation Presented) A new route toward puupehenone-related bioactive metabolites from (-)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (-)-15-oxopuupehenol, together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished.