851317-57-2Relevant academic research and scientific papers
Novel and potent cyclic cyanamide-based cathepsin K inhibitors
Deaton, David N.,Hassell, Anne M.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Shewchuk, Lisa M.,Tavares, Francis X.,Willard Jr., Derril H.,Wright, Lois L.
, p. 1815 - 1819 (2007/10/03)
Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-r
