186550-13-0

Basic information

• Product Name: tert-Butyl 3-aminopyrrolidine-1-carboxylate
• Synonyms: 1-BOC-3-AMINOPYRROLIDINE;1-N-BOC-3-AMINO-PYRROLIDINE;(+/-)-3-AMINO-1-BOC-PYRROLIDINE;3-AMINO-1-BOC-PYRROLIDINE;(+/-)-3-AMINO-1-N-BOC-PYRROLIDINE;3-AMINO-1-N-BOC-PYRROLIDINE;3-AMINOPYRROLIDINE, N1-BOC PROTECTED;3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS NO: 186550-13-0
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• EINECS: 1533716-785-6
• Product Categories: pharmacetical;Amines;Pyrrolidines;Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 186550-13-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 257.4 °C at 760 mmHg
• Flash Point: 91°C
• Appearance: /
• Density: 1.022
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.4710
• Storage Temp.: 2-8°C
• PKA: 9.55±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: tert-Butyl 3-aminopyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3-aminopyrrolidine-1-carboxylate(186550-13-0)
• EPA Substance Registry System: tert-Butyl 3-aminopyrrolidine-1-carboxylate(186550-13-0)

Safety Data

• Hazard Codes: C,Xi,Xn
• Statements: 36/37/38-44-41-22
• Safety Statements: 26-36/37/39
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 186550-13-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless low melting solid or liquid

InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/p+1/t7-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 79286-79-6 pyrrolidin-3-amine 
• 6627-89-0 tert-butyl phenyl carbonate 
• 141699-57-2 3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 862906-31-8 tert-butyl 3-(benzylamino)pyrrolidine-1-carboxylate 
• 113451-52-8 tert-butyl ester of 3-azidopyrrolidine-1-carboxylic acid 
• 325775-36-8 tert-butyl 3-{[(benzyloxy)carbonyl]amino}-1-pyrrolidinecarboxylate 
• 122684-33-7 methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 

Downstream Products

• 396729-75-2 1,1-dimethylethyl 3-(benzoylamino)-1-pyrrolidinecarboxylate 
• 864951-56-4 3-(2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 851317-57-2 3-(1-cyclohexylmethyl-propoxycarbonylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 609789-06-2 1-(tert-butoxycarbonyl)-3-(4-cyanophenylamino)pyrrolidine 
• 816468-39-0 1-(tert-butoxycarbonyl)-3-(2-methoxyphenylamino)pyrrolidine 
• 853577-87-4 1-(tert-butoxycarbonyl)-3-(4-fluorophenylamino)pyrrolidine 
• 949559-36-8 tert-butyl 3-(4-(2-fluoro-4-(2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamido)phenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-ylamino)pyrrolidine-1-carboxylate 
• 929019-02-3 C₁₉H₂₅N₃O₆ 
• 875340-76-4 tert-butyl 3-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carboxamido)pyrrolidine-1-carboxylate 
• 950649-08-8 tert-butyl 3-(pyrimidine-2-ylamino)-1-pyrrolidinecarboxylate 
• 1068162-37-7 (+/-)-tert-butyl 3-(5-methyl-2-nitrophenylamino)pyrrolidine-1-carboxylate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 147081-49-0 (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester 
• 1144524-64-0 1,1-dimethylethyl 3-({[4-(1-methylethyl)phenyl]carbonyl}amino)-1-pyrrolidinecarboxylate 

Relevant articles and documents

Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones

We describe the synthesis of derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione and their cytotoxicity for human tumor cells that express major determinants of altered anticancer drug response, the efflux pump P-glycoprotein, and non-functional p53. Nucleophilic substitution of methoxy groups in 4,11-dimethoxynaphtho[2,3-f]indole-5,10-dione with various ethylenediamines yielded the derivatives of 4,11-diaminonaphtho[2,3-f]indole-5,10-dione, the indole containing analogues of the antitumor agent ametantrone. The cytotoxicity of novel compounds for multidrug resistant, P-glycoprotein-expressing tumor cells is highly dependent on the N-substituent at the terminal amino group of the ethylenediamine moiety. Whereas p53 null colon carcinoma cells were less sensitive to the reference drug doxorubicin than their counterparts with wild type p53, the majority of novel naphthoindole derivatives were equally potent for both cell lines, regardless of the p53 status.

L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS A 5-HT4 RECEPTOR LIGANDS

The present invention relates to novel l,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. Formula (I) The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.

BIARYL CARBOXAMIDES

This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated disorders, and can be used in methods for treating atherosclerosis and preventing or reducing risk for atherosclerotic disease events. The compounds are also useful for treating or ameliorating pain, e.g. inflammatory pain and/or nociceptive pain, and for treating or ameliorating autoimmune and/or inflammatory diseases, among other conditions.