851318-54-2Relevant academic research and scientific papers
Absolute stereochemical assignment of SCH 71450, a selective dopamine D4 receptor antagonist, through enantioselective epimer synthesis
Wu, Hsin-Pei,Lu, Tai-Ni,Hsu, Nai-Yun,Chang, Che-Chien
, p. 2898 - 2905 (2013)
The absolute stereochemical assignment of SCH 71450, a selective dopamine D4 receptor antagonist, has been successfully confirmed through enantioselective epimer synthesis. An allyl substituent on the p-hydroxybenzyl group was demonstrated to be an appropriate protecting group for Noyori Ru-catalyzed asymmetric transfer hydrogenation of the imine derivative. The construction of the sugar moiety involved a β-glycosylation reaction assisted by neighboring group participation. By comparison with literature data, the absolute stereochemistry at the C-1 carbon on the tetrahydroisoquinoline core has been assigned the S configuration. Copyright
Perylenequinone natural products: Enantioselective synthesis of the oxidized pentacyclic core
Mulrooney, Carol A.,Morgan, Barbara J.,Li, Xiaolin,Kozlowski, Marisa C.
supporting information; experimental part, p. 16 - 29 (2010/04/26)
(Chemical Equation Presented) An enantioselective approach to the perylenequinone core found in the mold perylenequinone natural products is outlined. Specifically, the first asymmetric syntheses of helical chiral perylenequinones absent any additional st
DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS
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Page/Page column 30, (2010/02/11)
The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs
