1440095-48-6

Basic information

• Product Name: (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline
• Synonyms: (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline
• CAS NO: 1440095-48-6
• Molecular Weight: 491.63
• Mol File: 1440095-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline(1440095-48-6)
• EPA Substance Registry System: (1R)-1,2,3,4-tetrahydro-1-[(4-allyloxyphenyl)methyl]-6,7-bis(benzyloxy)isoquinoline(1440095-48-6)

Safety Data

• Hazardous Substances Data: 1440095-48-6(Hazardous Substances Data)

Upstream product

• 1440095-44-2 N-[2,4-bis(benzyloxy)phenethyl]-2-(4-allyloxyphenyl)acetamide 
• 72224-22-7 4-allyloxyphenylacetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 275385-78-9 C₁₁H₁₁ClO₂ 
• 851318-54-2 allyl (p-allyloxyphenyl)acetate 

Downstream Products

• 1440095-52-2 C₄₁H₃₉NO₅ 
• 1440545-91-4 SCH 71450 
• 1440095-56-6 C₃₈H₃₅NO₅ 

Relevant articles and documents

Absolute stereochemical assignment of SCH 71450, a selective dopamine D4 receptor antagonist, through enantioselective epimer synthesis

The absolute stereochemical assignment of SCH 71450, a selective dopamine D4 receptor antagonist, has been successfully confirmed through enantioselective epimer synthesis. An allyl substituent on the p-hydroxybenzyl group was demonstrated to be an appropriate protecting group for Noyori Ru-catalyzed asymmetric transfer hydrogenation of the imine derivative. The construction of the sugar moiety involved a β-glycosylation reaction assisted by neighboring group participation. By comparison with literature data, the absolute stereochemistry at the C-1 carbon on the tetrahydroisoquinoline core has been assigned the S configuration. Copyright