851371-02-3Relevant academic research and scientific papers
Novel highly potent, structurally simple γ-trifluoromethyl γ-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)
Sani, Monica,Candiani, Gabriele,Pecker, Fran?oise,Malpezzi, Luciana,Zanda, Matteo
, p. 2393 - 2396 (2005)
The γ-trifluoromethyl γ-sulfone hydroxamate 1 was synthesized both in racemic and enantiomerically pure forms by means of a thia-Michael reaction of p-methoxythiophenol on achiral and chiral 3,3,3-trifluorocrotonoyl Michael acceptors. The (R)-1 enantiomer
A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst
Hayama, Noboru,Inamoto, Kiyofumi,Kimachi, Tetsutaro,Kobayashi, Yusuke,Miyazaki, Anna,Sekimoto, Eriko,Takemoto, Yoshiji
, p. 5572 - 5576 (2020/06/18)
An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported. Both enantiomers of the Michael adducts can be obtained in high enantioselectivity and good yield merely by changing the solvent. The origin of the chirality switch in the products was examined in each solventviaspectroscopic analyses.
