851375-22-9

Upstream product

• 956316-86-2 benzyl 2-(4-((1,3-dioxolan-2-yl)methyl)-5-(4-fluorophenyl)-1-isopropyl-1H-pyrazol-3-yl)ethylcarbamate 
• 956316-87-3 3-(4-fluoro-phenyl)-2-isopropyl-7,8-dihydro-2H-1,2,6-triaza-azulene-6-carboxylic acid benzyl ester 
• 851376-04-0 tert-butyl 3-(4-fluorophenyl)-2-isopropyl-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate 
• 956316-85-1 benzyl 3-(2-isopropylhydrazono)propylcarbamate 
• 459-57-4 4-fluorobenzaldehyde 
• 1046478-89-0 tert-butyl 4-(p-tolylsulfonylhydrazono)-piperidine-1-carboxylate 
• 141642-82-2 5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 188975-88-4 tert-butyl 4-oxoazepane-1-carboxylate 
• 851377-52-1 tert-butyl 2-isopropyl-3-(((trifluoromethyl)sulfonyl)oxy)-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate 

Relevant academic research and scientific papers

Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate

We report here the synthesis and characterization of a dual 5-HT7 / 5-HT2 receptor antagonist 3-(4-Fluoro-phenyl)-2-isopropyl-2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene (4j). 4j is a high affinity 5-HT7 and 5-HT2A/su

Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles

Saturated bicyclic pyrazoles represent an important class of biologically active molecules, but their preparation can be hampered by labor-intensive synthesis of required starting materials. A convenient one- or two-step procedure for the synthesis of sat

Convergent synthesis of a 5HT7/5HT2 dual antagonist

The development of an efficient and convergent route to 3-(4-fluorophenyl)-2-isopropyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine (1), a potent 5HT7/5HT2 dual antagonist, is described. Significant features of this route are: (a) a r

PROCESS FOR THE PREPARATION OF SUBSTITUTED 2,4,5,6,7,8-HEXAHYDRO-1,2,6-TRIAZA-AZULENE DERIVATIVES

The present invention is directed to processes for the preparation of substituted 2, 4, 5, 6, 7, 8 - hexahydro -1, 2, 6 - triaza-azulene derivatives of formula (I) and (II), useful for the treatment of disease states mediated by serotonin receptor activity.

METHODS FOR THE PREPARATION OF PYRAZOLE-CONTAINING COMPOUNDS

The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity.