851376-90-4

Upstream product

• 100-44-7 benzyl chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 141642-82-2 5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 851377-09-8 3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-1H-1,2,6-triazaazulene-6-carboxylic acid tert-butyl ester 
• 851376-82-4 1-benzyl-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-1H-1,2,6-triazaazulene-6-carboxylic acid tert-butyl ester 
• 6113-62-8 2-(4-chlorophenyl)benzo[d][1,3,2]dioxaborole 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1073-62-7 N-benzylhydrazine hydrochloride 

Relevant academic research and scientific papers

Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

The synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine is described using a regioselective assembly of a pyrazole ring fused to an azepine ring. Two different approaches were examined for t

PROCESS FOR THE PREPARATION OF SUBSTITUTED 2,4,5,6,7,8-HEXAHYDRO-1,2,6-TRIAZA-AZULENE DERIVATIVES

The present invention is directed to processes for the preparation of substituted 2, 4, 5, 6, 7, 8 - hexahydro -1, 2, 6 - triaza-azulene derivatives of formula (I) and (II), useful for the treatment of disease states mediated by serotonin receptor activity.

FUSED HETEROCYCLIC COMPOUNDS

Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.