851389-20-3Relevant academic research and scientific papers
Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands
Limburg, David C.,Thomas IV, Bert E.,Li, Jia-He,Fuller, Mike,Spicer, Dawn,Chen, Yi,Guo, Hongzhi,Steiner, Joseph P.,Hamilton, Gregory S.,Wu, Yong-Qian
, p. 3867 - 3870 (2003)
As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biologica
Asymmetric synthesis of optically active decahydroisoquinolines useful in HIV-1 protease inhibitor synthesis
Trova, Michael P.,McGee Jr., Kevin F.
, p. 5951 - 5954 (2007/10/02)
An efficient synthesis of amino acid ester 8 is described featuring an asymmetric aza-Diels-Alder reaction of diene 5 and chiral imine 6 which establishes the asymmetry at C-3. Hydrogenation of 7 provides 8 with the desired asymmetry at C-4a and C-8a.
