851428-76-7Relevant academic research and scientific papers
Efficient approach to the unknown isoxazolo[3,4-d]thieno[2,3-b]pyridine system by regioselective intramolecular nitrone cycloadditions
Broggini, Gianluigi,Chiesa, Katja,De Marchi, Ivan,Martinelli, Michela,Pilati, Tullio,Zecchi, Gaetano
, p. 3525 - 3531 (2007/10/03)
An effective approach to the new isoxazolo[3,4-d]thieno[2,3-b]pyridine system was provided by way of an intramolecular nitrone cycloaddition. The required nitrones were built in good yields starting from thiophene-2-carboxylic acids. The same skeleton was achieved in optically active form employing chiral nitrones derived from N-α-methylbenzyl- and the N-α- hydroxymethylbenzyl-hydroxylamines. The absolute configuration of the products was assigned by X-ray analysis.
