851482-85-4Relevant academic research and scientific papers
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor
Chen, Chen,Jiang, Wanlong,Tran, Joe A.,Tucci, Fabio C.,Fleck, Beth A.,Markison, Stacy,Wen, Jenny,Madan, Ajay,Hoare, Sam R.,Foster, Alan C.,Marinkovic, Dragan,Chen, Caroline W.,Arellano, Melissa,Saunders, John
, p. 129 - 136 (2008/09/17)
A series of trans-4-phenylpyrrolidine-3-carboxamides were synthesized and characterized as potent ligands of the human melanocortin-4 receptor. Interestingly, a pair of diastereoisomers 13b displayed potent functional agonist and antagonist activity, resp
