851484-95-2

Usage

Uses

Used in Pharmaceutical Research:
2-Chloro-5-fluoro-pyridine-3-carbaldehyde is used as an intermediate compound for the synthesis of various therapeutic agents. Its unique structure, including chloro, fluoro sites, and an aldehyde group, allows for versatile chemical reactions that can lead to the development of new drugs.
Used in Chemical Reactions:
In the field of organic chemistry, 2-chloro-5-fluoro-pyridine-3-carbaldehyde is used as a reactant in various chemical reactions. The presence of the aldehyde group makes it a valuable building block for the synthesis of more complex molecules, which can be further utilized in different applications.
Used in Research and Development:
2-Chloro-5-fluoro-pyridine-3-carbaldehyde is employed as a research chemical, allowing scientists to explore its properties and potential applications. Its unique structure and reactivity make it an interesting subject for study, with the possibility of discovering new uses in various industries.

InChI:InChI=1/C6H3ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-3H

Upstream product

• 38186-88-8 2-chloro-5-fluoronicotinic acid 
• 870063-52-8 2-chloro-3-hydroxymethyl-5-fluoropyridine 

Downstream Products

• 1430745-43-9 (1R,3s,5S)-tert-butyl 3-((1r,4R)-4-(3-cyano-5-fluoropyridin-2-yloxy)cyclohexyloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 791644-48-9 2-chloro-5-fluoronicotinonitrile 

Relevant academic research and scientific papers

Preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine

The invention discloses a preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine, and belongs to the field of medicinal chemistry. The method specifically comprises the following steps: S1, carrying out reduction reaction on 2-chloro-5-fluoronicotinic acid serving as a starting point to obtain 2-chloro-3-hydroxymethyl-5-fluoropyridine; S2,carrying out oxidation reaction on the 2-chloro-3-hydroxymethyl-5-fluoropyridineto obtain 2-chloro-3-formyl-5-fluoropyridine; S3, enabling that the 2-chloro-3-formyl-5-fluoropyridine is subjected to ring closing through hydrazine hydrate, so that 5-fluoro-1H-pyrazolo [3, 4-b] pyridine is obtained; and S4, carrying out an iodination reaction on the 5-fluoro-1H-pyrazolo [3, 4-b] pyridine, so as to obtain the 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine. The four-step reaction of the preparation method does not use strongly corrosive acidic materials, so that the preparation method has the advantages of high safety operability, small damage to equipment and facilities, high safety operability in material storage, transfer and use links, avoidance of diazonium salt reaction for releasing nitrogen in the prior art, high safety controllability, mild reaction conditions, higher safety, simplicity in operation, high yield, and suitability for industrial production.

HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS

Disclosed are heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. Also disclosed are methods of treating or preventing cancer using the heterocyclic heteroaromatic macrocyclic ether compounds, pharmaceutically acceptable salts of the compounds, and pharmaceutical compositions thereof.