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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-fluoro-3-(hydroxymethyl)pyridine serves as a key intermediate in the development of various pharmaceuticals. Its unique chemical structure allows for the creation of new drug molecules with specific therapeutic properties, making it instrumental in advancing medicinal chemistry and drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, 2-chloro-5-fluoro-3-(hydroxymethyl)pyridine is utilized as an intermediate for synthesizing a range of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby contributing to increased agricultural productivity.
Used in Organic Synthesis:
2-Chloro-5-fluoro-3-(hydroxymethyl)pyridine is employed as a valuable building block in organic synthesis. Its reactivity and functional groups make it suitable for a wide array of chemical reactions, facilitating the production of diverse organic compounds for various applications across different industries.

InChI:InChI=1/C6H5ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-2,10H,3H2

Upstream product

• 38186-88-8 2-chloro-5-fluoronicotinic acid 
• 847729-27-5 2-chloro-5-fluoronicotinic acid methyl ester 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 

Downstream Products

• 1350653-23-4 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 851484-95-2 2-chloro-5-fluoropyridine-3-carbaldehyde 

Relevant academic research and scientific papers

Preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine

The invention discloses a preparation method of 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine, and belongs to the field of medicinal chemistry. The method specifically comprises the following steps: S1, carrying out reduction reaction on 2-chloro-5-fluoronicotinic acid serving as a starting point to obtain 2-chloro-3-hydroxymethyl-5-fluoropyridine; S2,carrying out oxidation reaction on the 2-chloro-3-hydroxymethyl-5-fluoropyridineto obtain 2-chloro-3-formyl-5-fluoropyridine; S3, enabling that the 2-chloro-3-formyl-5-fluoropyridine is subjected to ring closing through hydrazine hydrate, so that 5-fluoro-1H-pyrazolo [3, 4-b] pyridine is obtained; and S4, carrying out an iodination reaction on the 5-fluoro-1H-pyrazolo [3, 4-b] pyridine, so as to obtain the 5-fluoro-3-iodo-1H-pyrazolo [3, 4-b] pyridine. The four-step reaction of the preparation method does not use strongly corrosive acidic materials, so that the preparation method has the advantages of high safety operability, small damage to equipment and facilities, high safety operability in material storage, transfer and use links, avoidance of diazonium salt reaction for releasing nitrogen in the prior art, high safety controllability, mild reaction conditions, higher safety, simplicity in operation, high yield, and suitability for industrial production.

TOPICAL FORMULATIONS

Provided herein are gelled topical formulations for the treatment of skin diseases comprising: a) a MEK inhibitor; b) one or more organic solvents in an amount of about 70% to about 99% by weight; and c) a gelling agent; wherein the one or more organic solvents are selected from the group consisting of C2-6 alcohol, a C2-6 alkylene glycol, a di-(C2-6 alkylene) glycol, a polyethylene glycol, C1-3 alkyl-(OCH2CH2)1-5-OH, DMSO, ethyl acetate, acetone, N-methyl pyrrolidone, benzyl alcohol, glycerin, and an oil; the gelling agent is hydroxypropyl cellulose having a molecular weight ranging from about 40,000 Dato about 2,500,000 Da; and wherein the gelled topical formulation has a viscosity of from 1 to 25,000 cps; and DMSO, when present, is combined with at least one other of said organic solvents such that DMSO is present in an amount of less than 50% by weight.

ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF BIRTHMARKS

Provided herein are compounds and pharmaceutical compositions thereof for treating a birthmark in a subject in need thereof, wherein the compound is according to any one of formula (1), (II), (III), (IV), and (V). wherein X1, X2, X3, R1, R2, R2a, R13, R13a, R23, R23a, R23b, R33, R33a, R33b, R43, R43a, R51, R53, R53a, R53b, bond "a", and subscript n are described herein.

ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF SKIN CANCERS

Provided herein are compounds and pharmaceutical compositions thereof for treating a skin cancer in a subject in need thereof, wherein the compound is according to any one of formula (I), (II), (III), (IV), and (V): wherein X1, X2, X3, R1, R2, R2a, R13, Rl3a, R23, R23a, R23b, R33, R33a, R33b, R43, R43a, R51, R53, R53a, R53b, bond "a", and subscript n are described herein.

HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY

The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.