85149-52-6

Upstream product

• 120-72-9 indole 
• 92289-43-5 imidazole-1-carboxylic acid methylphenylamide 
• 98-95-3 nitrobenzene 
• 15249-31-7 N-phenyl-N-methyl-2-propynamide 
• 100-65-2 N-Phenylhydroxylamine 

Relevant academic research and scientific papers

A general and scalable synthesis of polysubstituted indoles

A consecutive 2-step synthesis of N-unprotected polysubstituted indoles bearing an electron-withdrawing group at the C-3 position from readily available nitroarenes is reported. The protocol is based on the [3,3]-sigmatropic rearrangement of N-oxyenamines generated by the DABCO-catalyzed reaction of N-arylhydroxylamines and conjugated terminal alkynes, and delivers indoles endowed with a wide array of substitution patterns and topologies.

AlMe3-mediated regio- and chemoselective reactions of indole with carbamoyl electrophiles

Herein, we report the regio- and chemoselective reactions of indole with carbamoyl electrophiles in presence of AlMe3. Indole-3-carboxamide was prepared in one-step from a reaction of indole with tertiary carbamoylimidazole in the presence AlMe