85152-75-6

Upstream product

• 43165-51-1 sodium benzoylformate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 611-73-4 Benzoylformic acid 
• 873-76-7 para-Chlorobenzyl alcohol 
• 614-16-4 Benzoylacetonitrile 
• 611-71-2 MANDELIC ACID 
• 622-95-7 4-chlorobenzyl bromide 
• 106-43-4 para-chlorotoluene 
• 98-86-2 acetophenone 
• 120-46-7 1,3-diphenylpropanedione 
• 85152-72-3 3-(4-chlorobenzyl)-4-phenyl-1,2,3-oxadiazol-3-ium-5-olate 

Relevant academic research and scientific papers

Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source

A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).

Visible Light Promotes Decyanation Esterification Reaction of β - Ketonitriles with Dioxygen and Alcohols to α-Ketoesters

A green and mild method has been developed for the conversion of β-ketonitriles into α-ketoesters under catalyst-free conditions. A plausible mechanism is that visible light promotes singlet oxygen generation to form the products through oxidative C-H bond functionalization and C-C σ -bond cleavage.

Synthesis method of pharmaceutical intermediate benzyl ester compound

The invention relates to a synthesis method of a benzyl ester compound capable of serving as a pharmaceutical intermediate and shown in a following formula (III). The synthesis method comprises the steps that a compound shown in the following formula (I) and a compound shown in the following formula (II) react in an organic solvent in the presence of a catalyst, an oxidant and an accelerant, and after the reaction is completed, after-treatment is performed so as to obtain the compound shown in the following formula (III) (show in the description), wherein R1 is selected from H, C1-C6 alkyls, C1-C6 alkoxys or halogens, R2 is selected from H, C1-C6 alkyls or halogens; R3 is selected from H or C1-C6 alkyls, and X represents halogen. The target product can be obtained by the adoption the method and through combined selection and coordination of the novel composite catalyst, the oxidant and the accelerant in a high-yield mode, and the brand new synthesis method is used for synthesis of the compound and has good application prospect and industrialized production potential on the aspect of pharmaceutical intermediate synthesis technologies.

Metal-free oxidative esterification of acetophenones with alcohols: A facile one-pot approach to α-ketoesters

A novel and efficient oxidative esterification method for the synthesis of α-ketoesters has been developed under mild and environmentally benign conditions, which is a facile one-pot approach to α-ketoesters from commercially available acetophenones with alcohols, especially under metal-free conditions, with broad substrate scope. A possible mechanism is proposed on the basis of a series of control experiments and DMSO18 isotopic labelling experiments.

Iron-Catalyzed Esterification of Benzyl C-H Bonds to Form α-Keto Benzyl Esters

An atom-economic and efficient non-precious metal-catalyzed esterification of benzyl C-H bonds has been developed. A variety of α-keto benzyl esters have been accessed in good yields through the reactions between benzyl derivatives and benzoylformic acids using iron trifluoride as a catalyst in the presence of di-tert-butyl peroxide under an inert atmosphere. This strategy provides a straightforward access to linearly expanded α-keto benzyl esters. A plausible reaction mechanism is proposed.

Cu-catalyzed aerobic oxidative esterification of acetophenones with alcohols to ?±-ketoesters

Copper-catalyzed aerobic oxidative esterification of acetophenones with alcohols using molecular oxygen has been developed to form a broad range of ?±-ketoesters in good yields. In addition to reporting scope and limitations of our new method, mechanism studies are reported that reveal that the carbonyl oxygen in the ester mainly originated from dioxygen.

Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: An approach to α-ketoesters

The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of α-ketoesters has been developed. This method combines C-C σ-bond cleavage, dioxygen activation and oxidative C-H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to α-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.

Reaction of Sydnones with Oxygen

The reaction of 3-benzyl- and 3-(p-chlorobenzyl)-4-phenylsydnones (1a and 1b) and of 3-benzylsydnone (1c) with oxygen at room temperature in the dark is described.Possible rationalizations for the formation of the products obtained are suggested.