851545-79-4

Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-4-(thiazol-2-ylmethoxy)aniline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs, particularly those targeting fungal infections and cancerous cells.
Used in Agrochemical Industry:
In the agrochemical sector, 3-chloro-4-(thiazol-2-ylmethoxy)aniline is employed as an intermediate in the production of pesticides and other crop protection agents. Its antifungal properties contribute to the development of effective solutions for managing fungal diseases in agriculture.
Used in Dye Industry:
3-chloro-4-(thiazol-2-ylmethoxy)aniline is utilized as a key intermediate in the synthesis of dyes. Its aromatic structure and functional groups enable the creation of dyes with specific color characteristics and properties, suitable for various applications in textiles, plastics, and other industries.
Used in Research and Development:
3-chloro-4-(thiazol-2-ylmethoxy)aniline is also used in research and development for exploring its potential biological activities. Studies are being conducted to understand its antifungal and antitumor properties, which could lead to the discovery of new therapeutic agents and applications in medicine.
It is important to handle 3-chloro-4-(thiazol-2-ylmethoxy)aniline with care, as it may pose hazards to human health and the environment. Proper safety measures and disposal methods should be followed to minimize any potential risks associated with this chemical compound.

Upstream product

• 619-08-9 2-chloro-4-nitrophenol 
• 851545-78-3 2-((2-chloro-4-nitrophenoxy)methyl)thiazole 

Downstream Products

• 1630042-67-9 N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine 
• 1012041-42-7 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine 
• 1630042-68-0 C₂₈H₂₃ClN₆O₃S 
• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 
• 1630042-71-5 C₂₂H₁₉ClN₆O₂S 
• 1630042-70-4 C₂₂H₁₉ClN₆O₂S 
• 845272-21-1 Varlitinib 

Relevant academic research and scientific papers

Preparation method of medicine for treating bile duct cancer

The invention belongs to the field of medical industry, and discloses a preparation method of a medicine for treating bile duct cancer. The preparation method of the drug Varlitinib for treating bileduct cancer comprises the following steps: with 2-amino-5-nitrobenzoic acid as a starting material, carrying out cyclization and chlorination on 2-amino-5-nitrobenzoic acid and methylimidazole acetateso as to synthesize an intermediate I; with 2-chloro-5-nitrophenol as a starting material, carrying out 2-chloromethylthiazole substitution and nitro reduction to synthesize an intermediate II; with1-amino-2-propanol as a starting material, carrying out a cyclization reaction of BTC, and carrying out chlorination to synthesize an intermediate III; and carrying out C-N coupling and nitro reduction on the intermediate I and the intermediate II, and finally carrying out a C-N coupling reaction on the intermediate I and the intermediate II and an intermediate III to synthesize Varlitinib. The method is simple and convenient to synthesize, short in route, economical in raw materials, high in yield, friendly to environment and suitable for industrial production.

Design, synthesis and bioactivities evaluation of novel quinazoline analogs containing oxazole units

A novel type of quinazoline derivatives, which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, have been synthesized and their biological activities were evaluated for anti-proliferative activities and EGFR inhibitory potency. Compound 12b demonstrated the most potent inhibitory activity (IC 50=0.95 μmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further study. The structures of the synthesized quinazoline analogs and all intermediates were comfirmed by 1H and 13C NMR, 2D NMR spectra, IR spectra and MS spectra. Copyright