851545-78-3

Usage

Uses

Used in Pharmaceutical Industry:
2-((2-chloro-4-nitrophenoxy)methyl)thiazole is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure with a thiazole ring and phenyl ring with chloro and nitro substituents makes it a valuable building block in the development of new pharmaceutical compounds.
Used in Agrochemical Industry:
2-((2-chloro-4-nitrophenoxy)methyl)thiazole is used as a building block in the synthesis of agrochemicals. Its potential biological activity and unique structure make it a promising candidate for the development of new agrochemicals.
Used in Chemical Research:
2-((2-chloro-4-nitrophenoxy)methyl)thiazole is used as a research compound to study its properties and potential applications. Further research is needed to fully understand its properties and explore its potential uses in various industries.

Upstream product

• 3364-78-1 2-chloromethyl-thiazole 
• 619-08-9 2-chloro-4-nitrophenol 
• 14542-12-2 (1,3-thiazol-2-yl)methanol 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Downstream Products

• 1630042-67-9 N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine 
• 1012041-42-7 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine 
• 1630042-68-0 C₂₈H₂₃ClN₆O₃S 
• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 
• 1630042-71-5 C₂₂H₁₉ClN₆O₂S 
• 1630042-70-4 C₂₂H₁₉ClN₆O₂S 
• 851545-79-4 3-chloro-4-(thiazol-2-ylmethoxy)aniline 
• 845272-21-1 Varlitinib 

Relevant academic research and scientific papers

Preparation method of medicine for treating bile duct cancer

The invention belongs to the field of medical industry, and discloses a preparation method of a medicine for treating bile duct cancer. The preparation method of the drug Varlitinib for treating bileduct cancer comprises the following steps: with 2-amino-5-nitrobenzoic acid as a starting material, carrying out cyclization and chlorination on 2-amino-5-nitrobenzoic acid and methylimidazole acetateso as to synthesize an intermediate I; with 2-chloro-5-nitrophenol as a starting material, carrying out 2-chloromethylthiazole substitution and nitro reduction to synthesize an intermediate II; with1-amino-2-propanol as a starting material, carrying out a cyclization reaction of BTC, and carrying out chlorination to synthesize an intermediate III; and carrying out C-N coupling and nitro reduction on the intermediate I and the intermediate II, and finally carrying out a C-N coupling reaction on the intermediate I and the intermediate II and an intermediate III to synthesize Varlitinib. The method is simple and convenient to synthesize, short in route, economical in raw materials, high in yield, friendly to environment and suitable for industrial production.

Design, synthesis and bioactivities evaluation of novel quinazoline analogs containing oxazole units

A novel type of quinazoline derivatives, which were designed by the combination of quinazoline as the backbone and oxazole scaffold as the substituent, have been synthesized and their biological activities were evaluated for anti-proliferative activities and EGFR inhibitory potency. Compound 12b demonstrated the most potent inhibitory activity (IC 50=0.95 μmol/L for EGFR), which could be optimized as a potential EGFR inhibitor in the further study. The structures of the synthesized quinazoline analogs and all intermediates were comfirmed by 1H and 13C NMR, 2D NMR spectra, IR spectra and MS spectra. Copyright