85157-03-5

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 65043-08-5 ethyl 4-diethoxyphosphoryl-3-oxobutanoate 
• 22252-14-8 (E)-3-(4-methylphenyl)-1-phenyl-2-propen-1-one 
• 141-97-9 ethyl acetoacetate 
• 4224-87-7 4-methyl-chalcone 
• 14802-30-3 (E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one 

Downstream Products

• 127143-08-2 ethyl 1-(2-cyanoethyl)-6-(4-methylphenyl)-2-oxo-4-phenyl-3-cyclohexene-1-carboxylate 
• 1206729-99-8 2-amino-5,6-dihydro-5-(4-methylphenyl)-7-phenylquinazolin-4-ol 
• 1290639-96-1 7-(4-methylphenyl)-9-phenyl-1,4-diazaspiro[4.5]deca-9-ene-6-ethyl carboxylate 
• 1190880-48-8 C₂₂H₂₁NO₂ 

Relevant academic research and scientific papers

Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives

Novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives were synthesized and characterized by using spectral techniques like IR, 1H NMR, 13C NMR, COSY, DEPT, and GC-MS. All these compounds were screened for anti-fungal, anti-bacterial and anti-oxidant activity. Cyclohexenone derivatives, in general, showed better anti-fungal and anti-bacterial activity than parent chalcones. Whereas, all the Indazole derivatives showed very good anti-oxidant activity and some were also found to be active as anti-bacterial agent. Among the screened compounds, 15 was found to be most active as anti-fungal agent (against Rhizoctonia solani, LC 50 = 2.36 μg mL-1), 15b was found to be most active anti-bacterial agent (against Klebsiella pneumonia, MIC = 24.68 μg mL -1) and 14b emerged as most active anti-oxidant (IC50 = 19.81 μg mL-1).

Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents

An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 μg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 μg/mL.

Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents

A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.

1H and 13C NMR spectral study of some 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones - A study of four-bond 1H-1H couplings

Nine 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones 2a-2i have been synthesized. For all these compounds, 1H and 13C NMR spectra have been recorded. For two compounds, 2D spectra have been recorded. The spectral data suggest that thes

A simple and practical method for the synthesis of 2-amino-5,6-dihydro-5,7- diarylquinazolin-4-ols

(Chemical Equation Presented) We report an efficient and new method of synthesis of 2-amino-5,6-dihydro-5,7-diarylquinazolin-4-ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50-72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis.

Microwave assisted rapid and efficient. synthesis of new 3-ethoxy-4,6-diaryl-4,5- Dihydro-2,1-benzisoxazoles

A simple, extremely fast and efficient synthesis of new 3- ethoxy-4,6-diaryl-4,5-dihydro2,l-benzisoxazoles has been achieved under microwave irradiation.

Synthesis and characterization of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols - A new series of fused indazole derivatives

A novel class of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols is synthesized and characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR, D2O exchanged 1H NMR, and two-dimensional HSQC spectra.

Michael addition catalyzed by potassium hydroxide under ultrasound

Michael addition of chalcone with active methylene compound such as diethyl malonate, nitromethane and ethyl acetoacetate catalyzed by potassium hydroxide in anhydrous ethanol results Michael adducts in 75-98% yield under ultrasound irradiation in 25-90 m