85157-04-6

Upstream product

• 22252-15-9 trans-4-methoxychalcone 
• 105-53-3 diethyl malonate 
• 109-77-3 malononitrile 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 22375-46-8 3-(4-Methoxyphenyl)-5-oxo-5-phenylpentansaeure 
• 22252-15-9 trans-4-methoxychalcone 
• 105-53-3 diethyl malonate 
• 857841-35-1 C₂₄H₂₉N₃O₆ 
• 1345614-30-3 diethyl 2-hydroxy-2-(1-(4-methoxyphenyl)-3-oxo-3-phenylpropyl)malonate 

Relevant academic research and scientific papers

Exploring bis-(amino)cyclopropenylidene as a non-covalent Br?nsted base catalyst in conjugate addition reactions

Bis-(amino)cyclopropenylidene has been utilised as a non-covalent Br?nsted base catalyst in the 1,6-conjugate addition of carbon nucleophiles to p-QMs. This protocol makes it possible to access unsymmetrical diaryl- and triarylmethanes in good to excellen

Hypoiodite-catalysed oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds: A facile and versatile approach to substituted furans and cyclopropanes

Through hypoiodite catalysis, oxidative cyclisation of Michael adducts of chalcones with 1,3-dicarbonyl compounds for divergent synthesis of either furans or cyclopropanes is developed. The selective synthesis of major products is achieved depending on the use of different reaction conditions or substrates.

Zinc-Mediated Allylation Followed by Lactonization of Dialkyl 2-(3-Oxo-1,3-diarylpropyl)malonates: Construction of δ-Lactones with Multiple Stereocenters

A variety of polysubstituted δ-lactones containing three or four stereocenters were prepared from various dialkyl 2-(3-oxo-1,3-diarylpropyl)malonates by a Barbier-type zinc-mediated allylation or cyclohexenylation of the keto group, followed by intramolec

Phase-transfer catalyzed Michael addition reaction using a new C 2-symmetric quaternary ammonium salt derived from l-proline

A new C2-symmetric quaternary ammonium salt easily prepared from l-proline, was developed and used as an efficient phase-transfer catalyst (PTC) in Michael addition reaction of various active methylene compounds to aromatic enones. Malonate est

The Michael addition of active methylene compounds to chalcone derivatives using a catalytic amount of iodine and K2CO3 at room temperature

A convenient method for the Michael addition of active methylene compounds to chalcone derivatives has been developed using the inexpensive and environmentally friendly reagent I2/K2CO3 at room temperature. The method is m

1H and 13C NMR studies of some 1, 1 -bis(carbethoxy)-2-aryl-4-phenyl/(4- chlorophenyl)-4-oxobutane and their derivatives

The 1H and 13C NMR spectral features of l, l-bis(carbethoxy)-2-aryl-4- phenyl/(4-chlorophenyl)-4-oxobutane la-j and their carbonyl derivatives 2a-e are discussed in the light of their diastereotopic characteristics and preferred conformational structures

Tetraethylammonium superoxide induced Michael addition of active methylene compounds to chalcones

Michael addition of active methylene compounds to chalcones using in-situ generated tetraethylammonium superoxide results in the formation of Michael adducts in 69-84% yield under mild reaction conditions, at room temperature.

Ionic liquid as catalyst and solvent: the remarkable effect of a basic ionic liquid, [bmIm]OH on Michael addition and alkylation of active methylene compounds

A basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, catalyzes the Michael addition of active methylene compounds to conjugated ketones, carboxylic esters and nitriles. It further catalyzes the addition of thiols to α,β-acetylenic ketones and alkylation of 1,3-dicarbonyl and -dicyano compounds. The Michael addition to α,β-unsaturated ketones proceeds in the usual way, giving the monoaddition products, whereas addition to α,β-unsaturated esters and nitriles leads exclusively to the bis-addition products. The α,β-acetylenic ketones undergo double conjugate addition with thiols producing β-keto 1,3-dithio-derivatives. In the alkylation reaction the acyclic 1,3-diketones are monoalkylated, whereas cyclic ketones undergo dialkylation under identical conditions. All these reactions were carried out without any organic solvent. The ionic liquid can also be recycled.

A mild, efficient, and green procedure for Michael addition of active methylene compounds to chalcones under microwave irradiation

A simple, rapid, and highly efficient method has been developed for the Michael addition of active methylene compounds to chalcones using potassium carbonate and water under microwave irradiation. The method is totally exempt of organic solvents, and pure

Ionic liquid as catalyst and reaction medium. The dramatic influence of a task-specific ionic liquid, [bmIm]OH, in Michael addition of active methylene compounds to conjugated ketones, carboxylic esters, and nitriles

(Chemical Equation Presented) A task-specific ionic liquid, [bmIm]OH, has been introduced as a catalyst and as a reaction medium in Michael addition. Very interestingly, although the addition to α,β-unsaturated ketones proceeds in the usual way, giving the monoaddition products, this ionic liquid always drives the reaction of open-chain 1,3-dicarbonyl compounds with α,β-unsaturated esters and nitriles toward bis-addition to produce exclusively bis-adducts in one stroke.