851670-79-6Relevant academic research and scientific papers
Preparation of 2- and 4-arylmethyl N-substituted and N,N-disubstituted anilines via a green , multicomponent reaction
Rosamilia, Anthony E.,Scott, Janet L.,Strauss, Christopher R.
, p. 1525 - 1528 (2005)
(Chemical Equation Presented) A new, green, regioselective, one-step, multicomponent reaction of an aldehyde possessing a nonenolizable carbonyl function, cyclohex-2-enone (or a derivative thereof), and primary or secondary amines afforded 2-N-substituted arylmethyl anilines or 4-N,N-disubstituted arylmethyl anilines, respectively. Yields and regioselectivities were good. Evidence for a pathway involving imine and iminium intermediates is presented along with examples demonstrating amenability of the process to combinatorial chemistry.
Selective N-alkylation of arylamines with alkyl chloride in ionic liquids: Scope and applications
Monopoli, Antonio,Cotugno, Pietro,Cortese, Marina,Calvano, Cosima Damiana,Ciminale, Francesco,Nacci, Angelo
supporting information; experimental part, p. 3105 - 3111 (2012/06/30)
An efficient N-selective alkylation of primary aromatic amines in molten quaternary ammonium salts, as the solvent, under relatively mild and base-free conditions is presented. On the basis of the Kamlet-Taft parameters and the nucleophilicity of the IL (ionic liquid) anions, the influence of the ionic liquid was evaluated. This protocol was validated on a larger multigram scale and with the syntheses of bioactive heterocycles (e.g., 1,4-benzothiazine and quinoxalines) and new efficient MALDI matrixes. Copyright
Thermal reactions of N-Alkyl-2-benzylaniline and N-Alkyl-N′-phenyl-o- phenylenediamine: An unusual route to 2-phenylindole and 2-phenylbenzimidazole
Creencia, Evelyn Cuevas,Taguchi, Kei,Horaguchi, Takaaki
, p. 837 - 843 (2008/09/21)
(Chemical Equation Presented) Thermal cyclization reactions of N-alkyl-2-benzylaniline 1a-d and N-alkyl-N′-phenyl-o-phenylenediamine 2a-b were carried out expecting to get seven-membered heterocyclic compounds. However, the results show that aside from th
CHEMICAL PROCESSES AND COMPOUNDS DERIVED THEREFROM
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Page/Page column 46, (2010/10/19)
The present invention relates to N-substituted anilines and derivatives thereof and in particular to chemical processes for the preparation of N-substituted anilines and derivatives thereof.
