851729-16-3Relevant academic research and scientific papers
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents
Bhat,Dhar,Puri,Saxena,Shanmugavel,Qazi
, p. 3177 - 3180 (2007/10/03)
A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.
Synthesis of 3,5-diphenyl-1H-pyrazoles
Bhat,Puri,Qurishi,Dhar,Qazi
, p. 1135 - 1142 (2007/10/03)
An efficient and convenient synthesis of 3,5-diphenyl-1N-pyrazoles from chalcones by the action of hydrazine hydrate on chalcone-epoxide followed by simultaneous dehydration is reported. Copyright Taylor & Francis, Inc.
