851755-58-3

Basic information

• Product Name: montelukast tert-butylamine salt
• Synonyms: montelukast tert-butylamine salt
• CAS NO: 851755-58-3
• Molecular Weight: 659.333
• Mol File: 851755-58-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: montelukast tert-butylamine salt(CAS DataBase Reference)
• NIST Chemistry Reference: montelukast tert-butylamine salt(851755-58-3)
• EPA Substance Registry System: montelukast tert-butylamine salt(851755-58-3)

Safety Data

• Hazardous Substances Data: 851755-58-3(Hazardous Substances Data)

Upstream product

• 920739-17-9 (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate 
• 75-64-9 tert-butylamine 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 807638-71-7 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol 
• 158966-92-8 montelukast 

Downstream Products

• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 

Relevant articles and documents

PREPARATION OF MONTELUKAST

Processes for the preparation of montelukast and its salts.

Process for the Preparation of Montelukast and Its Pharmaceutically Acceptable Salts

An improved process for the preparation of Montelukast and its pharmaceutically acceptable salts comprises of reacting (S) Benzenepropanol α-[3-[2-(7-chloro2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate compound of formula (II) with 1-(mercapto methyl)cyclo propane acetic acid or its ester or nitrile in presence of alkali or alkaline carbonates and/or alkali or alkaline earth metal alkoxide in a suitable polar aprotic solvent with or without combination of C1-C4 alcoholic solvents and then treating with organic amine in a suitable ester and/or acetone and/or aliphatic or aromatic hydrocarbon solvents, and converting the corresponding amine salt compound of montelukast into its sodium salt compound of formula (I) using sodium ion source in methanol, without converting into montelukast free acid.

IMPROVED PROCESS FOR PURE MONTELUKAST SODIUM THROUGH PURE INTERMEDIATES AS WELL AS NOVEL AMINE SALTS

The present invention provides an improved process for the preparation of highly pure montelukast sodium through highly pure diol intermediate compound of formula (2) and (1)-(mercapto methyl) cyclopropane acetic acid methyl ester compound of formula (4) or mercaptomethyl cyclopropane acetic acid compound of formula (7). The present invention also provides novel organic amine salts of montelukast.