85176-32-5Relevant academic research and scientific papers
Parallel solid-phase synthesis of zatebradine analogues as potential If channel blockers
Bom, Anton,Booth, Susan,Bruin, John,Clark, John,Miller, Susan,Wathey, Bernard
, p. 2351 - 2354 (2007/10/03)
The first solid-phase synthesis of zatebradine 1 and its analogues is reported. This has resulted in the preparation of compounds with increased ability to reduce the spontaneous beating of isolated guinea-pig atria in a concentration-dependent manner. One example, 8g, showed a maximum reduction of beating of 80% at 3 μM compared to a reduction of 40% at 3 μM with zatebradine 1.
