851769-60-3Relevant academic research and scientific papers
Design, synthesis, and antitumor activity of novel acylate of 6-OH at 1- O-acetylbritannilactone
Liu, Shouxin,Feng, Jun,Liu, He,Li, Junzhang,Tian, Xia
, p. 200 - 205 (2015/04/14)
N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.
Design, synthesis, and anti-tumor activity of (2-O-alkyloxime-3-phenyl)- propionyl-1-O-acetylbritannilactone esters
Liu, Shouxin,Liu, He,Yan, Weiying,Zhang, Li,Bai, Naisheng,Ho, Chi-Tang
, p. 2783 - 2789 (2007/10/03)
The extracts of Inula britannica have anti-inflammatory, anti-bacterial, anti-hepatitic, and anti-tumor activities. Various sesquiterpene lactones with cytotoxic properties including 1-O-acetylbritannilactone (1) have been isolated from this Chinese medic
