851778-92-2

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 103763-12-8 5-O-tert-butyldiphenylsilyl-α-L-arabinofuranose 
• 808109-49-1 2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-5-allyl-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethyl ester 
• 808109-82-2 2,2-Dimethyl-propionic acid (2S,3S,4S,5S)-5-allyl-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 252904-80-6 (2S,3R,4R,5S)-2-Allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3,4-diol 
• 808109-90-2 2,2-Dimethyl-propionic acid (2S,3S,4S,5S)-5-((S)-2,3-dihydroxy-propyl)-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 252904-78-2 Acetic acid (2S,3S,4S)-4-acetoxy-5-allyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 808109-89-9 2-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-methoxy-tetrahydro-furan 

Downstream Products

• 808109-92-4 (2S,3S,4S,5S)-2-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-methoxy-4-(4-methoxy-benzyloxy)-5-vinyl-tetrahydro-furan 
• 808109-91-3 [(2S,3S,4S,5S)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-acetaldehyde 
• 851778-93-3 2-[(2S,3S,4S,5S)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-ethanol 

Relevant academic research and scientific papers

Structurally simplified macrolactone analogues of halichondrin B

Structurally simplified macrolactone analogues of halichondrin B (e.g., 47, IC50 = 0.67 nM) were identified that retain the potent cell growth inhibitory activity of the natural product in vitro. A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.