808109-82-2

Upstream product

• 103763-12-8 5-O-tert-butyldiphenylsilyl-α-L-arabinofuranose 
• 252904-80-6 (2S,3R,4R,5S)-2-Allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3,4-diol 
• 252904-78-2 Acetic acid (2S,3S,4S)-4-acetoxy-5-allyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 808109-89-9 2-allyl-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-3-methoxy-tetrahydro-furan 
• 3282-30-2 pivaloyl chloride 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 808109-49-1 2,2-Dimethyl-propionic acid (2S,3S,4R,5S)-5-allyl-3-hydroxy-4-methoxy-tetrahydro-furan-2-ylmethyl ester 

Downstream Products

• 808109-90-2 2,2-Dimethyl-propionic acid (2S,3S,4S,5S)-5-((S)-2,3-dihydroxy-propyl)-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 808109-50-4 2,2-Dimethyl-propionic acid (2S,3S,4S,5S)-5-((R)-2,3-dihydroxy-propyl)-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 808109-51-5 (2S,3S,4S,5S)-2-[(R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-methoxy-4-(4-methoxy-benzyloxy)-5-vinyl-tetrahydro-furan 
• 808109-92-4 (2S,3S,4S,5S)-2-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-3-methoxy-4-(4-methoxy-benzyloxy)-5-vinyl-tetrahydro-furan 
• 808109-85-5 [(2S,3S,4S,5S)-5-[(R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-methanol 
• 851778-92-2 [(2S,3S,4S,5S)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-methanol 
• 808109-91-3 [(2S,3S,4S,5S)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-acetaldehyde 
• 851778-93-3 2-[(2S,3S,4S,5S)-5-[(S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-furan-2-yl]-ethanol 

Relevant academic research and scientific papers

Structurally simplified macrolactone analogues of halichondrin B

Structurally simplified macrolactone analogues of halichondrin B (e.g., 47, IC50 = 0.67 nM) were identified that retain the potent cell growth inhibitory activity of the natural product in vitro. A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.

Intermediate compounds for preparing macrocylcic analogs

Intermediate compounds of the formulas for use in the preparation of macrocyclic analogs.