85187-13-9Relevant academic research and scientific papers
A kind of preparation method for treating keratoconjunctival
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Paragraph 0039; 0040, (2017/01/12)
The invention belongs to the field of chemical synthesis, and in particular relates to a novel method for preparing herbicide, namely glufosinate-ammonium. The method comprises the following steps: conducting addition reaction on methyl phosphonic acid ester compounds and DL-2-hydroxy-3-crotonic acid ester compounds to obtain hydroxybutyric acid ester derivatives, and conducting acidification and ammonification reaction on the hydroxybutyric acid ester derivatives to obtain a glufosinate-ammonium compound. The method can avoid using high-toxic cyanide and obviously shortens a reaction route, so that the reaction steps of a process for preparing glufosinate-ammonium are reduced, the operation is simpler and more convenient, and many times of recrystallization is not needed for removing ammonium salt. The cost is reduced, and the method is completely suitable for large-scale production.
Grass ammonium phosphine method for the preparation of
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Paragraph 0072; 0078; 0079, (2017/01/17)
The invention belongs to the field of chemical synthesis, and particularly relates to a new preparation method of a glufosinate-ammonium weed killer. The preparation method is characterized in that methyl phosphorus dichloride reacts with alcohol so as to prepare a methyl phosphonate compound IV, and then the methyl phosphonate compound IV reacts with acrolein so as to prepare a methyl propionaldehyde phosphonate compound II; the methyl propionaldehyde phosphonate compound II is subjected to Bucherer-Bergs ring-closure reaction so as to prepare a hydantoin derivative shown in a formula III, and the hydantoin derivative is subjected to hydrolysis reaction so as to prepare the glufosinate-ammonium compound shown in a formula I. The preparation method of the glufosinate-ammonium has the advantages that required conditions are mild, the detection is easy, the required raw materials are easily available and low in cost, the yield of the obtained product is high, the obtained product has high purity, and ammonium salt is removed without needing recrystallization over and over again.
