676-97-1 Usage
Description
METHYLPHOSPHONIC DICHLORIDE is a low melting solid or colorless to pale yellow liquid with a pungent odor. It is strongly irritating to the skin and can cause irreversible damage upon contact. It is very toxic by ingestion, inhalation, or skin absorption and is considered combustible, although it may be difficult to ignite.
Uses
1. Used in Chemical Synthesis:
METHYLPHOSPHONIC DICHLORIDE is used as a reagent for the Suzuki reaction, a widely employed method in organic chemistry for the formation of carbon-carbon bonds, particularly in the synthesis of complex organic molecules.
2. Used in Pharmaceutical Industry:
METHYLPHOSPHONIC DICHLORIDE is used as an intermediate in the synthesis of various pharmaceutical compounds due to its reactive nature and ability to form carbon-carbon bonds.
3. Used in Agrochemical Industry:
METHYLPHOSPHONIC DICHLORIDE is used as a building block in the production of certain agrochemicals, such as pesticides and herbicides, where its reactivity and ability to form carbon-carbon bonds are advantageous.
4. Used in Material Science:
METHYLPHOSPHONIC DICHLORIDE is used as a precursor in the development of new materials, such as polymers and coatings, due to its potential to form carbon-carbon bonds and its reactive nature.
5. Used in Research and Development:
METHYLPHOSPHONIC DICHLORIDE is used as a research compound for exploring new chemical reactions and developing novel synthetic pathways in various fields, including pharmaceuticals, agrochemicals, and material science.
Air & Water Reactions
Fumes in moist air to form hydrogen chloride. Reacts with water to form hydrochloric acid, reaction may be violent.
Reactivity Profile
METHYLPHOSPHONIC DICHLORIDE is incompatible with water, strong oxidizing agents, alcohols, bases (including amines).. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Poisonous if inhaled or swallowed. Contact causes severe burns to skin and eyes.
Fire Hazard
METHYLPHOSPHONIC DICHLORIDE may burn but does not ignite readily. May ignite other combustible materials (wood, paper, oil, etc.). Reacts violently with water. Flammable poisonous gases may accumulate in tanks and hopper cars. Runoff to sewer may create fire or explosion hazard. Contact causes severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution. Violent reaction with water.
Safety Profile
Poison by inhalation.
A corrosive irritant to the eyes, skin,
and mucous membranes. When heated
to decomposition it emits toxic fumes
of Cland POx.
Potential Exposure
Highly flammable; mists or Vapors may
form explosive mixture with air. Reacts with moist air forming
fumes of hydrogen chloride; may spontaneously ignite. Reacts
with water or alcohol, forming hydrochloric acid. The reaction
may be violent and ignite unreacted material. Incompatible
with oxidizers (chlorates, nitrates, peroxides, permanganates,
perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials,
strong bases, strong acids, oxoacids, epoxides, amines, ethers.
May react violently, possibly explosively, when mixed with
ethers and trace amounts of metal salts.
Shipping
UN9206 Methyl phosphonic dichloride, Hazard
class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive
material. Domestic (United States), Inhalation Hazard Zone
B. UN3390 Toxic by inhalation liquid, corrosive, n.o.s.
with an LC50 # 1000 mL/m3 and saturated vapor concentration ≥ 10 LC50 Hazard Class: 6.1; Labels: 6.1-
Poisonous materials, 8-Corrosive material, Technical Name
Required, Inhalation Hazard Zone B
Purification Methods
Methylphosphonic dichloride [676-97-1] M 132.9, m 33o, 33-37o, b 53-54o/10mm, 64-6 7o/20.5mm, 86o/44mm, 162o/760mm, d 4 1.4382. Fractionally redistil it until the purity as checked by hydrolysis and acidimetry for Clis correct and the distillate should solidify on cooling. [Kinnear & Perren J Chem Soc 3437 1952, Crofts & Kosolapoff J Am Chem Soc 75 3379 1952, for IR see McIvor et al. Can J Chem 34 1611 1956, Beilstein 4 IV 3509.]
Waste Disposal
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. All federal, state, and local environmental
regulations must be observed
Check Digit Verification of cas no
The CAS Registry Mumber 676-97-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,7 and 6 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 676-97:
(5*6)+(4*7)+(3*6)+(2*9)+(1*7)=101
101 % 10 = 1
So 676-97-1 is a valid CAS Registry Number.
InChI:InChI=1/CH3Cl2OP/c1-5(2,3)4/h1H3
676-97-1Relevant articles and documents
Poly(phosphonate)s via olefin metathesis: Adjusting hydrophobicity and morphology
Steinbach, Tobias,Alexandrino, Evandro M.,Wahlen, Christian,Landfester, Katharina,Wurm, Frederik R.
, p. 4884 - 4893 (2014)
Olefin metathesis step-growth (acyclic diene metathesis (ADMET)) and chain-growth (ring-opening metathesis) polymerization was used to prepare linear poly(phosphonate)s with variable hydrophilicity. The first phosphonate monomer, i.e., di(undec-10-en-1-yl) methylphosphonate, for ADMET polymerization was developed, and potentially degradable and biocompatible, unsaturated poly(phosphonate)s were prepared with molecular weights up to 23 000 g mol -1 with molecular weight dispersities D -1 (homopolymer) and 47 000 g mol-1 (copolymers). Poly(phosphonate)s are potentially hydrolytically degradable materials and therefore promising materials for biomedical applications.
Solid-Phase Synthesis of a Special Phosphorylated Peptide as a Biomarker for LC-MS/MS Detection for OPNA Exposure
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Liu, Shilei,Liu, Jingquan
, p. 986 - 988 (2017)
A synthesis of d5-VX adducted nonapeptide via solid-phase approach has been developed. The d5-VX peptide could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. The Kaiser test was utilized to ensure the right connections of all of the amino acids. This method offers an access to the synthesis and detection of other phosphorylated nonapeptides.
Solid-phase synthesis for novel nerve agent adducted nonapeptides as biomarkers
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Li, Xiaosen,Zhang, Chunhong,Liu, Shilei,Liu, Jingquan
, p. 1437 - 1440 (2017)
An efficient synthesis of d5-VX adducted nonapeptide and d15-GD adducted nonapeptide via solid-phase approach has been developed. The deuterated peptides could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. This method also offers an access to the synthesis and detection of other phosphorylated nonapeptides.
RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE
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Page/Page column 22; 23, (2018/12/13)
The invention relates to resorcinol derivatives of formula (I) and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, and the racemic mixtures thereof, alone or as a mixture. The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds (I).
Methylphosphonic acid dimethyl heptyl esters synthetic method
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Paragraph 0035; 0037, (2017/06/03)
The invention relates to a synthesis method of dimethylheptyl methylphosphonate, and aims to solve the difficulty in raw material measurement and the safety problem caused by the use of the high-pressure reaction kettle in the existing technique, thereby lowering the production cost. The invention has the advantages of simple operating procedure, high output and high yield, and is suitable for industrial production. The method comprises the following steps: adding an acyl-chlorination reagent into a reaction vessel, wherein the acyl-chlorination reagent is thionyl chloride, phosphorous pentachloride or triphosgene; dropwisely adding dimethyl methyl phosphonate (DMMP) into the acyl-chlorination reagent at room temperature and adding catalytic amount of catalyst, wherein the consumption of the acyl-chlorination reagent is 2-5 times of the DMMP (0.6-1.5 times for triphosgene) on mol basis, and the catalyst is N,N-di-substituted-formamide or N-containing aromatic heterocyclic ring or N-substituted N-containing aromatic heterocyclic ring or tertiary amine; and uniformly stirring at room temperature.