676-97-1Relevant articles and documents
Poly(phosphonate)s via olefin metathesis: Adjusting hydrophobicity and morphology
Steinbach, Tobias,Alexandrino, Evandro M.,Wahlen, Christian,Landfester, Katharina,Wurm, Frederik R.
, p. 4884 - 4893 (2014)
Olefin metathesis step-growth (acyclic diene metathesis (ADMET)) and chain-growth (ring-opening metathesis) polymerization was used to prepare linear poly(phosphonate)s with variable hydrophilicity. The first phosphonate monomer, i.e., di(undec-10-en-1-yl) methylphosphonate, for ADMET polymerization was developed, and potentially degradable and biocompatible, unsaturated poly(phosphonate)s were prepared with molecular weights up to 23 000 g mol -1 with molecular weight dispersities D -1 (homopolymer) and 47 000 g mol-1 (copolymers). Poly(phosphonate)s are potentially hydrolytically degradable materials and therefore promising materials for biomedical applications.
Vibrational spectra and possible conformers of dimethylmethylphosphonate by normal mode analysis
Moravie, R. M.,Froment, F.,Corset, J.
, p. 1015 - 1024 (1989)
A careful assignment of the i.r. and Raman spectra of CH3P(O)(OCH3)2, CD3P(O)(OCH3)2, CH3P(O)(OCD3)2 and CD3P(O)(OCD3)2 and a comparison with those of the parent molecules CH3OP(O)Cl2 and CD3OP(O)Cl2 suggest that only one conformer exists in the liquid state.This conformer is probably close to the most stable one calculated by CNDO/2 and ab initio STO-3G methods, with one CH3O group trans and the other cis to the P=O group.The characteristic modes of the CP(O)(OC)2 skeleton are analysed through a force field calculation.It is shown that the stretching vibrations of the single bonds PC and PO are strongly coupled.As already observed for carboxylic esters, it is shown that only mixed skeletal modes and mostly the bending modes are sensitive to the conformation of the methoxy groups around the P-O single bond.On the other hand the ν(P=O) mode does not vary for the different conformers, and the extra components appearing in its vicinity, as well as in that of the ν(P-C) main vibrational mode, are best understood as being due to Fermi resonances with harmonic or combination tones coupling with these modes.
Solid-Phase Synthesis of a Special Phosphorylated Peptide as a Biomarker for LC-MS/MS Detection for OPNA Exposure
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Liu, Shilei,Liu, Jingquan
, p. 986 - 988 (2017)
A synthesis of d5-VX adducted nonapeptide via solid-phase approach has been developed. The d5-VX peptide could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. The Kaiser test was utilized to ensure the right connections of all of the amino acids. This method offers an access to the synthesis and detection of other phosphorylated nonapeptides.
Solid-phase synthesis for novel nerve agent adducted nonapeptides as biomarkers
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Li, Xiaosen,Zhang, Chunhong,Liu, Shilei,Liu, Jingquan
, p. 1437 - 1440 (2017)
An efficient synthesis of d5-VX adducted nonapeptide and d15-GD adducted nonapeptide via solid-phase approach has been developed. The deuterated peptides could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. This method also offers an access to the synthesis and detection of other phosphorylated nonapeptides.
Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples
Rodin,Baygildiev,Krylov,Osipov,Krylov,Yashkir,Rybalchenko
, p. 2103 - 2107 (2019/11/29)
A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.
RESORCINOL DERIVATIVES FOR THEIR COSMETIC USE
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Page/Page column 22; 23, (2018/12/13)
The invention relates to resorcinol derivatives of formula (I) and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, and the racemic mixtures thereof, alone or as a mixture. The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds (I).
Method for synthesizing flame retardant intermediate methanephosphonic dichloride
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Page/Page column 5-7, (2018/11/10)
The invention discloses a method for synthesizing flame retardant intermediate methanephosphonic dichloride. The method comprises the following steps: A, adding sulfonyl chloride into a sealed reactor, and cooling to 0 to 5 DEG C in low temperature bath; B, slowly dropwise adding methanephosphonic dichloride into a reaction system, keeping the reaction temperature at 15 to 20 DEG C, wherein the dripping time is 1 to 3 hours; C, after the material is added, continuously stirring and reacting for 0.5 to 1 hour at the temperature of 0 to 30 DEG C; D, after the reaction is completed, distilling abyproduct thionyl chloride by virtue of decompression distillation, and collecting fraction at 40 to 50 DEG C; and E, continuously increasing the distilling temperature, decompression distilling, andobtaining the methanephosphonic dichloride product, and collecting the fraction at 70 to 80 DEG C. The method is mild in reaction condition, simple in operation, low in cost, free from adding and generating gases, high in safety, and easy in industrialized production; and the purity of the methanephosphonic dichloride product and the byproduct thionyl chloride can reach up to 98 percent or more, and the reaction yield is 95 percent or more.
Methylphosphonic acid dimethyl heptyl esters synthetic method
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Paragraph 0035; 0037, (2017/06/03)
The invention relates to a synthesis method of dimethylheptyl methylphosphonate, and aims to solve the difficulty in raw material measurement and the safety problem caused by the use of the high-pressure reaction kettle in the existing technique, thereby lowering the production cost. The invention has the advantages of simple operating procedure, high output and high yield, and is suitable for industrial production. The method comprises the following steps: adding an acyl-chlorination reagent into a reaction vessel, wherein the acyl-chlorination reagent is thionyl chloride, phosphorous pentachloride or triphosgene; dropwisely adding dimethyl methyl phosphonate (DMMP) into the acyl-chlorination reagent at room temperature and adding catalytic amount of catalyst, wherein the consumption of the acyl-chlorination reagent is 2-5 times of the DMMP (0.6-1.5 times for triphosgene) on mol basis, and the catalyst is N,N-di-substituted-formamide or N-containing aromatic heterocyclic ring or N-substituted N-containing aromatic heterocyclic ring or tertiary amine; and uniformly stirring at room temperature.
New method for synthesizing substituted phosphinate
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Paragraph 0022-0024, (2017/12/27)
The invention discloses a new method for synthesizing substituted phosphinate. The method comprises the step of generating the substituted phosphinate by reducing halogenated phosphonate under the effect of a reducing agent. The optimal preparation method for the substituted phosphinate is screened through a large number of experiments according to the invention; the whole process is reasonably designed; the technological operation is simple and efficient; especially, the optimal reaction conditions are screened, including reaction solvent, reaction temperature, reaction time and optimal reaction pH value; the reaction yield is obviously increased; the yield reaches up to 85-95%; the side reaction is less; the production cost is greatly lowered; the industrial production can be realized; and the method has a wide application prospect.
A reaction in the preparation of glyphosate, the application of the phosphine type flame retardant (by machine translation)
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Paragraph 0062-0064, (2018/12/13)
The invention relates to an application of a new intramolecular heterogeneous reaction of phosphor in the preparation of products of glyphosate, phosphine fire retardants and chloromethyl phosphonic dichloride. The application which develops a new approach of a synthetic route of the products and improves disadvantages of high original synthetic technology cost and large wastewater discharge amounts of the products can reach industrial design standards of clear production.
