676-97-1Relevant articles and documents
Poly(phosphonate)s via olefin metathesis: Adjusting hydrophobicity and morphology
Steinbach, Tobias,Alexandrino, Evandro M.,Wahlen, Christian,Landfester, Katharina,Wurm, Frederik R.
, p. 4884 - 4893 (2014)
Olefin metathesis step-growth (acyclic diene metathesis (ADMET)) and chain-growth (ring-opening metathesis) polymerization was used to prepare linear poly(phosphonate)s with variable hydrophilicity. The first phosphonate monomer, i.e., di(undec-10-en-1-yl) methylphosphonate, for ADMET polymerization was developed, and potentially degradable and biocompatible, unsaturated poly(phosphonate)s were prepared with molecular weights up to 23 000 g mol -1 with molecular weight dispersities D -1 (homopolymer) and 47 000 g mol-1 (copolymers). Poly(phosphonate)s are potentially hydrolytically degradable materials and therefore promising materials for biomedical applications.
Solid-Phase Synthesis of a Special Phosphorylated Peptide as a Biomarker for LC-MS/MS Detection for OPNA Exposure
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Liu, Shilei,Liu, Jingquan
, p. 986 - 988 (2017)
A synthesis of d5-VX adducted nonapeptide via solid-phase approach has been developed. The d5-VX peptide could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. The Kaiser test was utilized to ensure the right connections of all of the amino acids. This method offers an access to the synthesis and detection of other phosphorylated nonapeptides.
Solid-phase synthesis for novel nerve agent adducted nonapeptides as biomarkers
Li, Xinhai,Yuan, Ling,Wang, Qinggang,Liang, Longhui,Huang, Guilan,Li, Xiaosen,Zhang, Chunhong,Liu, Shilei,Liu, Jingquan
, p. 1437 - 1440 (2017)
An efficient synthesis of d5-VX adducted nonapeptide and d15-GD adducted nonapeptide via solid-phase approach has been developed. The deuterated peptides could be used as the isotope-labeled internal standard for LC-MS/MS detecting the BuChE-OPNA biomarkers. This method also offers an access to the synthesis and detection of other phosphorylated nonapeptides.
Method for synthesizing flame retardant intermediate methanephosphonic dichloride
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Page/Page column 5-7, (2018/11/10)
The invention discloses a method for synthesizing flame retardant intermediate methanephosphonic dichloride. The method comprises the following steps: A, adding sulfonyl chloride into a sealed reactor, and cooling to 0 to 5 DEG C in low temperature bath; B, slowly dropwise adding methanephosphonic dichloride into a reaction system, keeping the reaction temperature at 15 to 20 DEG C, wherein the dripping time is 1 to 3 hours; C, after the material is added, continuously stirring and reacting for 0.5 to 1 hour at the temperature of 0 to 30 DEG C; D, after the reaction is completed, distilling abyproduct thionyl chloride by virtue of decompression distillation, and collecting fraction at 40 to 50 DEG C; and E, continuously increasing the distilling temperature, decompression distilling, andobtaining the methanephosphonic dichloride product, and collecting the fraction at 70 to 80 DEG C. The method is mild in reaction condition, simple in operation, low in cost, free from adding and generating gases, high in safety, and easy in industrialized production; and the purity of the methanephosphonic dichloride product and the byproduct thionyl chloride can reach up to 98 percent or more, and the reaction yield is 95 percent or more.
Methylphosphonic acid dimethyl heptyl esters synthetic method
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Paragraph 0035; 0037, (2017/06/03)
The invention relates to a synthesis method of dimethylheptyl methylphosphonate, and aims to solve the difficulty in raw material measurement and the safety problem caused by the use of the high-pressure reaction kettle in the existing technique, thereby lowering the production cost. The invention has the advantages of simple operating procedure, high output and high yield, and is suitable for industrial production. The method comprises the following steps: adding an acyl-chlorination reagent into a reaction vessel, wherein the acyl-chlorination reagent is thionyl chloride, phosphorous pentachloride or triphosgene; dropwisely adding dimethyl methyl phosphonate (DMMP) into the acyl-chlorination reagent at room temperature and adding catalytic amount of catalyst, wherein the consumption of the acyl-chlorination reagent is 2-5 times of the DMMP (0.6-1.5 times for triphosgene) on mol basis, and the catalyst is N,N-di-substituted-formamide or N-containing aromatic heterocyclic ring or N-substituted N-containing aromatic heterocyclic ring or tertiary amine; and uniformly stirring at room temperature.
