851885-30-8

Basic information

• Product Name: (R)-1-(2′-chlorophenyl)-2-propanol
• Synonyms: (R)-1-(2′-chlorophenyl)-2-propanol
• CAS NO: 851885-30-8
• Molecular Weight: 170.639
• Mol File: 851885-30-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-1-(2′-chlorophenyl)-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2′-chlorophenyl)-2-propanol(851885-30-8)
• EPA Substance Registry System: (R)-1-(2′-chlorophenyl)-2-propanol(851885-30-8)

Safety Data

• Hazardous Substances Data: 851885-30-8(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 701-06-4 1-(2′-chlorophenyl)-2-propanol 
• 6305-95-9 2-chlorophenylacetone 

Downstream Products

• 1238894-55-7 (R)-1-(2-chlorophenyl)propan-2-yl acetate 

Relevant articles and documents

Novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone

The invention discloses a novel non-metal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone. The preparation method of a chiral alcohol compound shown as formula IV comprises the following step of: reacting a ketone compound shown as formula V with hydrogen under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound to obtain the chiral alcohol compound shown as the formula IV; the preparation method of a chiral tetralone compound shown as formula VI comprises the following step of: under the catalysis of tri(4-hydrotetrafluorophenyl)boron and a chiral oxazoline compound, reacting an alpha, beta-unsaturated ketone compound shown as formula VII with hydrogen to obtain the chiral tetralone compound shown as the formula VI. The method has the advantages of easy synthesis of raw materials, mild reaction conditions, simple operation, high stereoselectivity and the like, the ee value of the product is up to 92%, and the yield is up to 99%.

Expanding the Substrate Specificity of Thermoanaerobacter pseudoethanolicus Secondary Alcohol Dehydrogenase by a Dual Site Mutation

Here, we report the asymmetric reduction of selected phenyl-ring-containing ketones by various single- and dual-site mutants of Thermoanaerobacter pseudoethanolicus secondary alcohol dehydrogenase (TeSADH). The further expansion of the size of the substrate binding pocket in the mutant W110A/I86A not only allowed the accommodation of substrates of the single mutants W110A and I86A within the expanded active site but also expanded the substrate range of the enzyme to ketones bearing two sterically demanding groups (bulky–bulky ketones), which are not substrates for the TeSADH single mutants. We also report the regio- and enantioselective reduction of diketones with W110A/I86A TeSADH and single TeSADH mutants. The double mutant exhibited dual stereopreference to generate the Prelog products most of the time and the anti-Prelog products in a few cases.

NOVEL TYROSINE KINASE INHIBITORS

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.