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851897-01-3

N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

    Cas No: 851897-01-3

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  • 851897-01-3 Structure

  • Basic information

    1. Product Name: N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide
    2. Synonyms: N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide
    3. CAS NO:851897-01-3
    4. Molecular Formula:
    5. Molecular Weight: 441.911
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 851897-01-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide(851897-01-3)
    11. EPA Substance Registry System: N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide(851897-01-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 851897-01-3(Hazardous Substances Data)

851897-01-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 851897-01-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,8,9 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 851897-01:
(8*8)+(7*5)+(6*1)+(5*8)+(4*9)+(3*7)+(2*0)+(1*1)=203
203 % 10 = 3
So 851897-01-3 is a valid CAS Registry Number.

851897-01-3Downstream Products

851897-01-3Relevant articles and documents

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

Norcross, Neil R.,Wilson, Caroline,Baraga?a, Beatriz,Hallyburton, Irene,Osuna-Cabello, Maria,Norval, Suzanne,Riley, Jennifer,Fletcher, Daniel,Sinden, Robert,Delves, Michael,Ruecker, Andrea,Duffy, Sandra,Meister, Stephan,Antonova-Koch, Yevgeniya,Crespo, Benigno,de Cózar, Cristina,Sanz, Laura M.,Gamo, Francisco Javier,Avery, Vicky M.,Frearson, Julie A.,Gray, David W.,Fairlamb, Alan H.,Winzeler, Elizabeth A.,Waterson, David,Campbell, Simon F.,Willis, Paul A.,Read, Kevin D.,Gilbert, Ian H.

supporting information, p. 1329 - 1335 (2019/07/17)

Herein we describe the optimization of a phenotypic hit against Plasmodium falciparum based on an aminoacetamide scaffold. This led to N-(3-chloro-4-fluorophenyl)-2-methyl-2-{[4-methyl-3-(morpholinosulfonyl)phenyl]amino}propanamide (compound 28) with low-nanomolar activity against the intraerythrocytic stages of the malaria parasite, and which was found to be inactive in a mammalian cell counter-screen up to 25 μm. Inhibition of gametes in the dual gamete activation assay suggests that this family of compounds may also have transmission blocking capabilities. Whilst we were unable to optimize the aqueous solubility and microsomal stability to a point at which the aminoacetamides would be suitable for in vivo pharmacokinetic and efficacy studies, compound 28 displayed excellent antimalarial potency and selectivity; it could therefore serve as a suitable chemical tool for drug target identification.

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