851967-66-3

Upstream product

• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 139545-04-3 [L-(trans)]-4-[(t-butoxycarbonyl)amino]-5-phenyl-2-pentenoic acid 
• 72155-45-4 Boc-L-phenylalaninal 
• 99298-05-2 (E)-(S)-4-tert-butoxycarbonylamino-5-phenyl-pent-2-enoic acid methyl ester 

Downstream Products

• 851967-89-0 [(R)-1-benzyl-3-(2-pyrrolidin-1-yl-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

GLYT2 MODULATORS

α-, β-, and γ-amino acid derivatives of formula I are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain. Formula I

Novel glycine transporter type-2 reuptake inhibitors. Part 2: β- and γ-amino acid derivatives

Several β- and γ-amino acid derivatives were prepared as glycine transport inhibitors and their ability to block the uptake of [ 14C]-glycine in COS7 cells transfected with human glycine transporter-2 (hGlyT-2) were evaluated. A range of lipoph