85202-79-5

Usage

Chemical family

Tetrazinane family

Type of compound

Thione derivative

Molecular weight

215.31 g/mol

Physical appearance

Yellowish crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Potential applications

Pharmaceutical industry

Use

Building block for the synthesis of other organic compounds

Importance

Valuable synthetic intermediate for the production of various pharmaceuticals and other organic products

Upstream product

• 100-52-7 benzaldehyde 
• 85202-77-3 bis(1-methylhydrazide)thiocarbonic acid 

Downstream Products

• 85202-81-9 1,5-Dimethyl-3-phenyl-[1,2,4,5]tetrazinane 
• 85202-83-1 1,5-Dimethyl-3-phenyl-6-thioxoverdazyl 

Relevant academic research and scientific papers

2,4-Dialkyl Substituted Carbono- and Thiocarbonohydrazides, Reactions with Carbonyl Compounds

2,4-Dialkyl substituted carbono- and thiocarbonohydrazides (4) were prepared from alkylhydrazines and phosgene or thiophosgene.Mono carbonyl compounds reacted with 4 (molar ratio 1:1) to yield hexahydro-1,2,4,5-tetrazines (9, 14; exception 13).Aldehydes in excess generally afforded dihydrazones (3); formaldehyde, however, yielded 1,1'-methylenebis(hexahydro-1,2,4,5-tetrazines) (10) as well as the bicyclic compounds 11 and 12.The constitution of 11 was confirmed by X-ray analysis of 11b.Dialdehydes and aliphatic or alicyclic α-diketones reacted with 4 to give double hexahydro-1,2,4,5-tetrazine derivatives (19), aryl substituted α-diketones on the other hand yielded cyclic dihydrazones (15) and/or mono-hexahydro-1,2,4,5-tetrazines (16).