852045-27-3

Upstream product

• 133218-74-3 4,5,6-tri-O-benzyl-1,2-anhydro-myo-inositol 
• 852109-35-4 (1S,2S,3S,4S,5R,6R)-3-azido-4,5,6-tris-benzyloxycyclohexane-1,2-diol 

Downstream Products

• 852045-29-5 (1S,2S,3R,4R,5S,6S)-3,4,5-tris-benzyloxy-6-phenethylaminocyclohexane-1,2-diol 
• 852045-30-8 (1S,2S,3R,4R,5S,6S)-3,4,5-tris-benzyloxy-6-octylaminocyclohexane-1,2-diol 

Relevant academic research and scientific papers

New aminocyclitols as modulators of glucosylceramide metabolism

A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided. The Royal Society of Chemistry 2005.