852181-19-2

Basic information

• Product Name: (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone
• Synonyms: (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone
• CAS NO: 852181-19-2
• Molecular Weight: 337.419
• Mol File: 852181-19-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone(852181-19-2)
• EPA Substance Registry System: (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone(852181-19-2)

Safety Data

• Hazardous Substances Data: 852181-19-2(Hazardous Substances Data)

Upstream product

• 581101-46-4 methyl 3-(2,4-dimethylphenyl)propanoate 
• 216881-36-6 3-(2,4-dimethylphenyl)-acrylic acid methyl ester 
• 1811-85-4 3-(2,4-dimethylphenyl)propionic acid 
• 859966-60-2 3-(2,4-dimethyl-phenyl)-propionyl chloride 
• 40217-17-2 (R)-4-(phenylmethyl)-2-oxazolidinone 

Downstream Products

• 852181-22-7 (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone 

Relevant articles and documents

Chiral building blocks: Enantioselective syntheses of benzyloxymethyl phenyl propionic acids

The synthesis of (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methoxyphenyl)- propionic acid, (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methylphenyl)propionic acid and (2S)-2-benzyl-oxymethyl-3-(2,4-dimethylphenyl)propionic acid has been achieved by TiCl4 mediated alkylation of the corresponding (4R)-4-benzyl-3-[3-(2-fluoro-4-methoxyphenyl-, 2-fluoro-4-methylphenyl-, 2,4-dimethylphenyl-)propionyl]-2-oxazolidinones, followed by hydrolysis of the chiral auxiliary. The stereochemistry of the alkylation reaction was confirmed by an X-ray crystal structure of (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2- fluoro-4-methylphenyl)propionyl]-2-oxazolidinone.