1811-85-4

Basic information

• Product Name: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID;3-(2,4-DIMETHYLPHENYL)PROPANOIC ACID
• CAS NO: 1811-85-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 1811-85-4.mol

Chemical Properties

• Boiling Point: 309.4°C at 760 mmHg
• Flash Point: 206.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(1811-85-4)
• EPA Substance Registry System: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(1811-85-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1811-85-4(Hazardous Substances Data)

Usage

Uses

Used in Pest Control Industry:
3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID is used as an antifeedant for the protection of pine trees against pine weevil. Its chemical properties deter the weevil from feeding on the pine trees, thus providing a means of biological control and reducing the need for chemical pesticides.
Used in Pharmaceutical Industry:
3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID serves as a potential delivery agent for biologically active compounds. Its unique structure allows for the effective transport and delivery of these compounds to their target sites within the body, enhancing their bioavailability and therapeutic effects. This application can be particularly beneficial in the development of new drugs and drug formulations, as well as in improving the efficacy of existing medications.

InChI:InChI=1/C11H14O2/c1-8-3-4-10(9(2)7-8)5-6-11(12)13/h3-4,7H,5-6H2,1-2H3,(H,12,13)

Upstream product

• 64-18-6 formic acid 
• 2234-20-0 2,4-dimethylstyrene 
• 15764-16-6 2,4-dimethylbenzaldehyde 
• 124-38-9 carbon dioxide 
• 61052-15-1 (E)-ethyl 3-(2,4-dimethylphenyl)acrylate 
• 95-47-6 o-xylene 
• 95-68-1 2,4-Xylidine 
• 824-55-5 2,4-dimethyl-benzyl chloride 
• 95-78-3 2,5-Dimethylaniline 
• 106-42-3 para-xylene 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 89-74-7 2,4-dimethylacetophenone. 
• 108-38-3 m-xylene 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 

Downstream Products

• 1355058-52-4 (+/-)-(4-chloro-2-{2-[3-(2,4-dimethylphenyl)propionyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenoxy)acetic acid 
• 852181-22-7 (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone 
• 852181-19-2 (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone 
• 581101-46-4 methyl 3-(2,4-dimethylphenyl)propanoate 
• 1685-81-0 4,6-dimethyl-2,3-dihydro-1H-inden-1-one 
• 859966-60-2 3-(2,4-dimethyl-phenyl)-propionyl chloride 
• 1202576-63-3 (3S)-3-(4-{[(1R)-4,6-dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid 
• 1202578-18-4 (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 
• 1202578-17-3 {[(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropyl]oxy}(triisopropyl)silane 
• 22484-28-2 5,7-dimethyl-1H-indene 
• 1685-82-1 4,6-dimethylindane 
• 214618-21-0 5-{5-[3-(2,4-Dimethyl-phenyl)-propyl]-thiophen-2-yl}-3,3-dimethyl-pentanoic acid 

Relevant articles and documents

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

An effective Pd-catalyzed hydrocarboxylation of aryl olefins with Ac2O and formic acid is described. A variety of 2- and 3-arylpropanoic acids can be regioselectively formed by the judicious choice of ligand without the use of toxic CO gas.

Iron-catalyzed, highly regioselective synthesis of α-aryl carboxylic acids from styrene derivatives and CO2

The iron-catalyzed hydrocarboxylation of aryl alkenes has been developed using a highly active bench-stable iron(II) precatalyst to give α-aryl carboxylic acids in excellent yields and with near-perfect regioselectivity. Using just 1 mol % FeCl2, bis(imino)pyridine 6 (1 mol %), CO 2 (atmospheric pressure), and a hydride source (EtMgBr, 1.2 equiv), a range of sterically and electronically differentiated aryl alkenes were transformed to the corresponding α-aryl carboxylic acids (up to 96% isolated yield). The catalyst was found to be equally active with a loading of 0.1 mol %. Preliminary mechanistic investigations show that an iron-catalyzed hydrometalation is followed by transmetalation and reaction with the electrophile (CO2).

CARBOXYLIC ACID COMPOUND

To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X re

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

Guanidino compounds

A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be formulated into pharmaceutical formulations and compositions.

Chiral building blocks: Enantioselective syntheses of benzyloxymethyl phenyl propionic acids

The synthesis of (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methoxyphenyl)- propionic acid, (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methylphenyl)propionic acid and (2S)-2-benzyl-oxymethyl-3-(2,4-dimethylphenyl)propionic acid has been achieved by TiCl4 mediated alkylation of the corresponding (4R)-4-benzyl-3-[3-(2-fluoro-4-methoxyphenyl-, 2-fluoro-4-methylphenyl-, 2,4-dimethylphenyl-)propionyl]-2-oxazolidinones, followed by hydrolysis of the chiral auxiliary. The stereochemistry of the alkylation reaction was confirmed by an X-ray crystal structure of (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2- fluoro-4-methylphenyl)propionyl]-2-oxazolidinone.

Bicyclic cyclohexylamines and their use as nmda receptor antagonists

Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's specification. disease. The substituents are defined in the specification.

Guanidino compounds

A variety of small, guanidino group-containing molecules capable of acting as MC4-R agonists are provided. The compounds have various structures provided herein. The compounds are useful in treating MC4-R mediated diseases and may be formulated into pharmaceutical formulations and compositions.

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).