1811-85-4

Basic information

• Product Name: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID;3-(2,4-DIMETHYLPHENYL)PROPANOIC ACID
• CAS NO: 1811-85-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 1811-85-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 309.4°C at 760 mmHg
• Flash Point: 206.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(1811-85-4)
• EPA Substance Registry System: 3-(2,4-DIMETHYLPHENYL)PROPIONIC ACID(1811-85-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1811-85-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1811-85-4 differently. You can refer to the following data:
1. 3-(2,4-Dimethylphenyl)propionic Acid
2. 3-(2,4-Dimethylphenyl)propionic Acid is used in the preparation of antifeedants for pine weevil. It may be a potential delivery agents for biologically active compounds

InChI:InChI=1/C11H14O2/c1-8-3-4-10(9(2)7-8)5-6-11(12)13/h3-4,7H,5-6H2,1-2H3,(H,12,13)

Upstream product

• 64-18-6 formic acid 
• 2234-20-0 2,4-dimethylstyrene 
• 1685-80-9 3-(2,4-Dimethylphenyl)-propensaeure 
• 16308-92-2 2,4-dimethylbenzyl alcohol 
• 61052-15-1 (E)-ethyl 3-(2,4-dimethylphenyl)acrylate 
• 95-47-6 o-xylene 
• 95-68-1 2,4-Xylidine 
• 95-78-3 2,5-Dimethylaniline 
• 106-42-3 para-xylene 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 89-74-7 2,4-dimethylacetophenone. 
• 108-38-3 m-xylene 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 
• 583-70-0 1-bromo-2,4-dimethylbenzene 

Downstream Products

• 581101-46-4 methyl 3-(2,4-dimethylphenyl)propanoate 
• 1355058-52-4 (+/-)-(4-chloro-2-{2-[3-(2,4-dimethylphenyl)propionyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenoxy)acetic acid 
• 1202576-63-3 (3S)-3-(4-{[(1R)-4,6-dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid 
• 1202578-18-4 (3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol 
• 1202578-17-3 {[(3S)-3-(4-{[(1R)-4,6-Dimethyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropyl]oxy}(triisopropyl)silane 
• 22484-28-2 5,7-dimethyl-1H-indene 
• 1685-82-1 4,6-dimethylindane 
• 214618-21-0 5-{5-[3-(2,4-Dimethyl-phenyl)-propyl]-thiophen-2-yl}-3,3-dimethyl-pentanoic acid 
• 852181-22-7 (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone 
• 852181-19-2 (4R)-4-benzyl-3-[3-(2,4-dimethylphenyl)propionyl]-2-oxazolidinone 
• 1685-81-0 4,6-dimethyl-2,3-dihydro-1H-inden-1-one 
• 859966-60-2 3-(2,4-dimethyl-phenyl)-propionyl chloride 

Relevant articles and documents

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Iron-catalyzed, highly regioselective synthesis of α-aryl carboxylic acids from styrene derivatives and CO2

The iron-catalyzed hydrocarboxylation of aryl alkenes has been developed using a highly active bench-stable iron(II) precatalyst to give α-aryl carboxylic acids in excellent yields and with near-perfect regioselectivity. Using just 1 mol % FeCl2, bis(imino)pyridine 6 (1 mol %), CO 2 (atmospheric pressure), and a hydride source (EtMgBr, 1.2 equiv), a range of sterically and electronically differentiated aryl alkenes were transformed to the corresponding α-aryl carboxylic acids (up to 96% isolated yield). The catalyst was found to be equally active with a loading of 0.1 mol %. Preliminary mechanistic investigations show that an iron-catalyzed hydrometalation is followed by transmetalation and reaction with the electrophile (CO2).

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.