852227-41-9Relevant academic research and scientific papers
Pyridine N-alkylatfon by lithium, magnesium, and zinc alkyl reagents: Synthetic, structural, and mechanistic studies on the bis(imino)pyridine system
Blackmore, Ian J.,Gibson, Vernon C.,Hitchcock, Peter B.,Rees, Charles W.,Williams, David J.,White, Andrew J. P.
, p. 6012 - 6020 (2005)
The 2,6-bis(α-iminoalkyl)pyridines 2,6-[ArNC(CR3)] 2C5H3N [R = H, D; Ar = 2,6-i-Pr 2C6H3 (DIPP), 2,6-Me2C 6H3 (DMP)] react with MeLi in Et2O to give a binary mixture of products: the pyridine N-methylated species 2,6-[ArNC(CR 3)]2C5H3N(Me)Li(OEt2) and the deprotonated/dedeuterated species 2-[ArNC(CR3)],6-[ArNC(=CR 2)]C5H3NLi(OEt2). For R = D, the product ratio is 2:1 in favor of the N-methylated product, while, for R = H, the deprotonated product is favored by 5:1, increasing to 8:1 in toluene solvent. Warming solutions of the N-methylated species leads to clean conversion to the thermodynamically preferred deprotonated species. Crossover experiments show that MeLi is re-formed and dissociates from the terdentate ligand before deprotonating the ketimine methyl unit. For MgR2 (R = Et, i-Pr) and ZnR2 (R = Et) reagents, N-alkylation products are formed exclusively, but derivatives containing bulky aryl substituents are found to undergo further rearrangement to 2-alkylated species, arising by migration of the alkyl group of the N-alkyl moiety to the adjacent ring carbon atom. The reversibility of the N-alkylation process has been probed using deuterio-labeled Mg alkyl reagents and mixed alkyl zinc species. A cationic zinc derivative is shown to undergo "reverse" alkyl migration, from the heterocycle nitrogen atom to the zinc center. EPR spectroscopy reveals a paramagnetic intermediate in which the unpaired electron is delocalized over the heterocycle and di-imine moieties of the ligand, indicating that the N-alkylation reactions proceed via single electron-transfer processes.
