852228-09-2

Basic information

• Product Name: Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate
• Synonyms: Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate
• CAS NO: 852228-09-2
• Molecular Formula: C₈H₉F₃N₂O₂
• Molecular Weight: 222.1644696
• Mol File: 852228-09-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate(852228-09-2)
• EPA Substance Registry System: Ethyl 1-methyl-5-(trifluoromethyl)-1H-pyrazole-3-carboxylate(852228-09-2)

Safety Data

• Hazardous Substances Data: 852228-09-2(Hazardous Substances Data)

Upstream product

• 1067233-79-7 4-trifluoromethyl-N-methylsydnone 
• 623-47-2 propynoic acid ethyl ester 

Relevant articles and documents

Synthesis of 4-fluoromethylsydnones and their participation in alkyne cycloaddition reactions

We report the synthesis and some structural studies of 4-trifluoromethyl, 4-difluoromethyl-, and 4-monofluoromethylsydnones. All but the latter compounds are stable and represent effective precursors to a range of pyrazoles after cycloaddition reactions with alkynes. The cycloadditions are generally highly regioselective and provide 5-fluoromethylpyrazole products, although we have observed that Bn-substituted sydnones can provide an unexpected alkyne insertion mode that generates the 3-fluoromethyl isomer.