85223-93-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2,5-dimethylphenol is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds.
Used in Organic Chemistry:
4-Bromo-2,5-dimethylphenol is utilized as a building block in the synthesis of other organic compounds, showcasing its importance in the realm of organic chemistry.
Used in Medical Applications:
4-Bromo-2,5-dimethylphenol is employed as an antibacterial and antifungal agent, leveraging its natural properties to combat infections in various medical settings.
Used in Personal Care Products:
It is used as a preservative in personal care products, ensuring the longevity and safety of these consumer goods by preventing microbial growth.
Used in Plastics and Rubber Industry:
4-Bromo-2,5-dimethylphenol is used as an additive in the production of plastics and rubber, enhancing the properties of these materials for specific applications.
Safety Considerations:
4-Bromo-2,5-dimethylphenol is classified as a hazardous substance, necessitating proper handling and storage procedures to ensure the safety of workers and the environment.

InChI:InChI=1/C8H9BrO/c1-5-4-8(10)6(2)3-7(5)9/h3-4,10H,1-2H3

Upstream product

• 93684-17-4 2,5-dimethyl-4-bromo-2,5-cyclohexadienone 
• 95-87-4 2,5-Dimethylphenol 

Downstream Products

• 205653-40-3 4-bromo-3,6-dimethyl-2-nitro-phenol 
• 108373-08-6 3-bromo-6-hydroxy-2,5-dimethyl-benzaldehyde 
• 58106-25-5 1-bromo-4-methoxy-2,5-dimethylbenzene 
• 851335-61-0 2-(4'-bromo-2',5'-dimethylphenoxy)-ethan-1-ol 
• 1579996-38-5 4-ethoxy-2-(3-hydroxypropyl)-3,6-dimethylphenol 
• 1579996-29-4 2-allyl-4-ethoxy-3,6-dimethylphenol 
• 1579996-25-0 1-allyloxy-4-ethoxy-2,5-dimethylbenzene 
• 99172-75-5 4-ethoxy-2,5-dimethylphenol 
• 1384267-65-5 2,2-difluoro-1-(4-bromo-2,5-dimethylphenoxy)butane 
• 1384267-45-1 C₁₈H₂₈F₂N₂O 
• 1384267-59-7 methyl N-{4-(2,2-difluoro-4-methylpentyloxy)-2,5-dimethylphenyl}formimidate 
• 1384267-69-9 2,2-difluoro-4-methyl-1-(4-amino-2,5-dimethylphenoxy)pentane 
• 1384267-44-0 C₁₆H₂₄F₂N₂O 
• 1384267-58-6 methyl N-{4-(2,2-difluorobutoxy)-2,5-dimethyl}phenylformimidate 

Relevant academic research and scientific papers

o-xylylene bis(triethyl ammonium tribromide) as a mild and recyclable reagent for rapid and regioselective bromination of anilines and phenols

Background: o-Xylylene bis(triethyl ammonium tribromide) (OXBTEATB) as a recyclable and high bromine containing di-(tribromide) reagent has been employed for the bromination of various organic substrates such as phenol and aniline or its derivatives. This catalyst can be recovered and reused several times. Methods: Aryl bromides shown in Table 1, were easily produced from bromination of aromatic compounds by OXBTEATB. This high-yield process lets the reagents to be recycled and reused. Results: As shown in Table 1, substituted anilines, phenols and β-naphthol were found to be the most reactive and immediately converted to the corresponding mono-brominated products by OXBTEATB. Conclusion: OXBTEATB can be considered a solidified bromine. This novel reagent has variable solubility in different polar protic and aprotic solvents but insoluble in non-polar aprotic solvent. Subsequently, OXBTEATB can be recognized as a more useful brominating and regioselective catalyst than the liquid bromine.

Efficient synthesis of rigid ladder polymers via palladium catalyzed annulation

We report a new method to synthesize rigid ladder polymers using efficient palladium catalyzed annulation reactions with low catalyst loading (1 mol %). Rigid ladder polymers with benzocyclobutene backbone linkages can be synthesized from copolymerization of readily accessible aryl dibromides and norbornadiene or polymerization of AB type monomers bearing norbornene and aryl bromide or triflate moieties. High molecular weight (10-40 kDa) rigid ladder polymers can be obtained with complete monomer conversions. Diverse monomers also gave different, fixed ladder polymer conformations. The ladder polymers exhibited excellent thermal stability, high carbonization yield, and large intrinsic porosity.

Synthesis and antioxidant activity of 5-hydroxycoumarans,c 6-hydroxychromanes and sulfur-containing derivatives on their base

A synthesis of 5-hydroxycoumarans, 6-hydroxychromanes and their dodecylthiomethyl- substituted derivatives was accomplished based on methylphenols through the intermediate preparation of 2-allyl-4-alkoxyphenols. The sulfur-containing compounds synthesized

Regioselective and high-yielding bromination of phenols and anilins using N-bromosaccharin and amberlyst-15

A regioselective and facile conversion method for bromination of anilines and phenols using N-bromosaccharine in the presence of a catalytic amount of Amberlyst-15 lead to enhancement of the reaction rate and yielded brominated products in good to excellent yields and short reaction times.

Efficient and regioselective bromination of aromatic compounds with ethylenebis(N-methylimidazolium) ditribromide (EBMIDTB)

A regioselective and highly efficient method for bromination of phenol and aniline derivatives using ethylenebis(N-methylimidazolium) ditribromide (EBMIDTB) as an efficient reagent in dichloromethane at ambient temperature is reported. The reagent can be recovered and reused several times.

Novel Phosphinic Acid-Containing Thyromimetics

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

First synthesis of nitro-substituted 2,2-diphenyl-2H-1-benzopyrans via the ipso-nitration reaction

The first synthesis of a series of nitro-substituted 2,2-diphenyl-2H-1-benzopyrans is reported. Our synthetic approach is based on a linear synthesis in two steps from appropriate brominated 2,2-diphenyl-2H-1-benzopyrans 12-17, which requires the preliminary preparation of bromophenols 7-11. These latter were easily obtained by the reaction of phenols 1-5 with a mild and selective brominating agent tetrabutylammonium tribromide (TBA·Br3). The key intermediates 12-17 were efficiently elaborated through an univocal classic chromenization between the commercially available 1,1-diphenyl-2-yn-1-ol and the brominated phenols 6-11. The compounds 12-17 so obtained were converted into arylboronic acids 18-23 by a metalation/boronylation sequence, followed by acid hydrolysis. From advanced building blocks 18-23, the introduction of nitro group, which constitutes the ultimate step of our strategy, was achieved by an ipso-nitration reaction using the Crivello's reagent. This highly selective method provides only the ipso-nitrated products 24-29 in moderate to high yield.

A convenient and regioselective oxidative bromination of electron-rich aromatic rings using potassium bromide and benzyltriphenylphosphonium peroxymonosulfate under nearly neutral reaction conditions

Regioselective oxidative bromination of electron-rich aromatic rings has been studied using potassium bromide as a bromine source in the presence of benzyltriphenylphosphonium peroxymonosulfate as oxidant under nearly neutral reaction conditions. In most cases we obtained monobrominated derivatives regioselectively and in good to high yields without the aid of strong acids.

NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS

The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.

Synthesis of soluble phenyl-substituted poly(p-phenylenevinylenes) with a low content of structural defects

The synthesis and characterization of two new soluble poly(p-phenylenevinylenes) (PPVs) are reported. The polymers are poly(2-(2′,5′-bis(octyloxy)benzene)-1,4-phenylenevinylene) (BOP-PPV) and poly(2-(2′,5′-bis(octyloxy)benzene)-5-methoxy-1,4-phenyleneviny