4-Bromo-2,5-dimethylphenol

Base Information

• Chemical Name: 4-Bromo-2,5-dimethylphenol
• CAS No.: 85223-93-4
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 2908199090
• Mol file: 85223-93-4.mol

Synonyms:phenol, 4-bromo-2,5-dimethyl-;TL80073466;4-Bromo-2,5-dimethylphenol 98%;

Chemical Property of 4-Bromo-2,5-dimethylphenol

Chemical Property:

• Vapor Pressure: 0.00821mmHg at 25°C
• Melting Point: 87 °C
• Refractive Index: 1.58
• Boiling Point: 259 °C at 760 mmHg
• PKA: 9.87±0.23(Predicted)
• Flash Point: 110.5 °C
• PSA: 20.23000
• Density: 1.471 g/cm³
• LogP: 2.77150
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-2,5-dimethylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2,5-dimethylphenol

There total 2 articles about 4-Bromo-2,5-dimethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,5-Dimethylphenol (95-87-4) → 4-bromo-2,5-dimethyl-phenol (85223-93-4)

Guidance literature:

With tetra-N-butylammonium tribromide; In methanol; dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.05.113

Reference yield:

2,5-dimethyl-4-bromo-2,5-cyclohexadienone (93684-17-4) → 4-bromo-2,5-dimethyl-phenol (85223-93-4)

Guidance literature:

With potassium bromide; In water; at 25 ℃; Rate constant; enolization;

DOI:10.1021/ja00288a030

Reference yield: 96.0%

4-bromo-2,5-dimethyl-phenol (85223-93-4) + methyl iodide (74-88-4) → 1-bromo-4-methoxy-2,5-dimethylbenzene (58106-25-5)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;

DOI:10.1021/ma011768m

upstream raw materials:

2,5-Dimethylphenol

2,5-dimethyl-4-bromo-2,5-cyclohexadienone

Downstream raw materials:

4,4'-dibromo-3,6,3',6'-tetramethyl-2,2'-(2-aza-propanediyl)-di-phenol

4-bromo-3,6-dimethyl-2-nitro-phenol

3-bromo-6-hydroxy-2,5-dimethyl-benzaldehyde

1-bromo-4-methoxy-2,5-dimethylbenzene

Refernces

• 1、 Liu, Sheng,Jin, Zexin,Teo, Yew Chin,Xia, Yan. "Efficient synthesis of rigid ladder polymers via palladium catalyzed annulation". supporting information. p. 17434 - 17437. Retrieved 2015/02/05.
• 2、 Baharfar,Alinezhad,Azimi,Salehian. "Regioselective and high-yielding bromination of phenols and anilins using N-bromosaccharin and amberlyst-15". experimental part. p. 863 - 865. Retrieved 2012/04/23.