852231-88-0Relevant academic research and scientific papers
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists
Perreira, Melissa,Jiang, Jian-Kang,Klutz, Athena M.,Gao, Zhan-Guo,Shainberg, Asher,Lu, Changrui,Thomas, Craig J.,Jacobson, Kenneth A.
, p. 4910 - 4918 (2005)
The dedifferentiation agent "reversine" [2-(4-morpholinoanilino)- N6-cyclohexyladenine 2] was found to be a moderately potent antagonist for the human A3 adenosine receptor (AR) with a K i value of 0.66 μM. This result pro
Dedifferentiation of Lineage-Committed Cells by a Small Molecule
Chen, Shuibing,Zhang, Qisheng,Wu, Xu,Schultz, Peter G.,Ding, Sheng
, p. 410 - 411 (2004)
Combinatorial libraries were screened for molecules that induce mouse myogenic lineage committed cells to dedifferentiate in vitro. A 2,6-disubstituted purine, reversine, was discovered that induces lineage reversal of C2C12 cells to become multipotent pr
Compositions and methods for inducing cell dedifferentiation
-
Page/Page column 15, (2008/06/13)
The present invention provides compositions and methods for dedifferentiating lineage committed mammalian cells.
