852248-59-0

Basic information

• Product Name: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol
• Synonyms: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol
• CAS NO: 852248-59-0
• Molecular Weight: 691.109
• Mol File: 852248-59-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol(852248-59-0)
• EPA Substance Registry System: (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol(852248-59-0)

Safety Data

• Hazardous Substances Data: 852248-59-0(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 852248-61-4 2,2-Dimethyl-propionic acid (4S,5S)-6,6,8-trimethyl-4-{(S)-2-methyl-1-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-allyl}-2-oxo-1,3-dioxa-spiro[4.5]dec-7-en-7-ylmethyl ester 
• 852248-60-3 (4S,5S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,6,8-trimethyl-4-{(S)-2-methyl-1-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-allyl}-1,3-dioxa-spiro[4.5]dec-7-en-2-one 

Relevant articles and documents

Synthesis of the AC ring of paclitaxel: Formation of the C ring by [3+2] cycloaddition with a preformed A ring

The stereoselective formation of the C ring was accomplished by nitrile oxide [3+2] cycloaddition of an intermediate with the A ring already constructed. We found that stereoelectronic effect to a 1,1-substituted alkene moiety is important in the reaction